Results 91 to 100 of about 13,064 (306)

Ontological levels of human integrity in the philosophy of Karl Marx 

Интеллект. Инновации. Инвестиции, 2019
In the conditions of the modern anthropological crisis, characterized by the disappearance of the human in society, fragmentation, atomization, depersonalization and loss of the integrity of human existence, attempts to philosophically comprehend the ...
P.N. Kondrashov
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fațetele multiple ale nemulțumirii populare: o schiță sociologică a protestelor in Piața Universității din ianuarie 2012

Sociologie Românească, 2012
This article addresses the January 2012 protests from Bucharest, Romania. Due to protesters’ high social diversity, their numerous themes of discontent, and rejection of all current politicians, these protests have been compared to Spain’s „Indignados ...
Cătălin Augustin Stoica
doaj  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The Tolerance as the Ethic Foundation of Social Economy into the Perspective of the Perspective of the “Included Third” in the Contextuality of Transmodernity [PDF]

Annals of Philosophy, Social and Human Disciplines, 2012
The tolerance is the form of the ethics, but the uninherent manifestation of the religious moralities, it developes socially profoundly, representing a pale projection of the christian ideal (challenge) of the principle of “love all people as you love ...
Antoniu Alexandru Flandorfer
doaj  

Comparison of the Social Atoms of Psychotic, Neurotic and Normals and devoloping Social Atom Test

FORUM for Group Psychotherapies and Processes
J.L. Moreno brought an innovative and revolutionary perspective to religion, philosophy, psychology, psychiatry, sociology, education, art and theatre. Moreno’s personality theory is considered as a biosocial interaction theory: a theory postulating that human beings have developed functions through constant interaction between the biological organism ...
openaire   +2 more sources

College social insertion: an investigation based on the minimum social atom

, 2008
Ao longo da história, os deficientes ocupam um lugar de marginalização e sua inserção depende, em grande parte, do contexto social. Este trabalho se propôs a mapear as redes sociais de alunos universitários com deficiência física a partir de uma leitura psicodramática e identificar como o aluno avalia sua inserção a partir dos papéis desempenhados ...
Auad, Juliana Cal, Conceição, Maria Inês Gandolfo   +1 more
openaire   +2 more sources