Results 91 to 100 of about 11,733,884 (255)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Atomization and combustion of a simple electrospray
, 2002 A simple atomizing device is presented capable of generating controlled spray by using an electric field either in isothermal and burning conditions. The stability operating range of controlling parameters (e.g.
A Cavaliere +3 more
core
Statistical dispersion of flapping events in air-assisted atomization
, 2021 Mixing layers between air and liquid are ubiquitous in nature and extremely common in industrial applications. Among the latest, air-assisted atomization is one of the predominant forcing used to induce breakup in liquid jets.
Crialesi-Esposito, Marco, +3 more
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
〈再録論文〉高圧雰囲気下における直噴式ディーゼル機関用微粒化促進ノズルの微粒化特性と流量特性の改善
, 2012 [Abstract] The purpose of this study is to improve atomization characteristics of a direct injection Diesel nozzle, which spray with large spray angle, short liquid core length and small droplet diameter are obtained.
タマキ, ノブシゲ +3 more
core
, 2005 Investigation of kerosene combustion in a Mach 2.5 flow was carried out using a model supersonic combustor with cross-section area of 51 mm × 70 mm and different integrated fuel injector/flameholder cavity modules.
赵建荣 +6 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Old and new forms of communication between the state and society on the way to a new social contract
RUDN journal of SociologyThe article considers the concept of social contract as a consensus between the state and the people. Based on the works of T. Hobbes, D. Locke, J.-J. Rousseau, C. Montesquieu, German social thought, in the context of reflections on the “legitimacy” of R.
R. I. Anisimov
doaj +1 more source