Results 71 to 80 of about 11,733,884 (255)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

La experiencia de la pobreza y su impacto en la organización popular de la ciudad de Lima

América Latina Hoy, 2009
RESUMEN: Con base en una investigación empírica realizada con técnicas cualitativas, se analiza la formación de organizaciones y acción colectiva en distintos tipos de estratos sociales en la ciudad de Lima.
María Ángeles LÓPEZ JIMÉNEZ
doaj   +3 more sources

Theoretical reflections about the concept of social networks

RAC: Revista de Administração Contemporânea
The recent literature on organizational theory has been dedicating a considerable attention to the relationship networks. In spite of this, however, it is possible to notice that there are many theoretical problems concerning this subject matter. In fact,
Humberto Elias Garcia Lopes
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Settlement sustainability as a result of the human and social capital development (on the example of the urban-type settlement Oktyabrskoe in the Republic of Crimea)

Крестьяноведение
Sustainable development of territories is one of the key goals of global and national policy. However, despite the resonance and financial assistance, many territories still lag behind and suffer from social-economic crises due to the peculiarities of ...
Timur Yu. Gusakov, Lyudmila K. Gusakova
doaj   +1 more source

Resilience and vulnerability of Ukrainians: The role of family during the war [PDF]

Problems and Perspectives in Management
The full-scale russian invasion of Ukraine led to numerous physical and moral challenges. The paper aims to estimate the role of family as a social resilience driver in managing wartime challenges on a regional level.
Andriana Kostenko, Volodymyr Semenov, Oksana Osetrova, Oleksandr Kubatko, Mykola Nazarov, Vitalii Stepanov   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Atomization of a G-DI spray with air dissolved in gasoline and mono-component fuels [PDF]

, 2019
A spray from a GDI multi-hole injector is used to investigate and compare the atomization results from different fuels in which air has been dissolved to promote the atomization.
R. Dondè, L. Araneo
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source