Results 51 to 60 of about 13,064 (306)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Parties and Ballot Access in Latin America: a new trend in a new political context [PDF]
, 2013 For the last ten years a group of Latin American countries have passed legal reforms raising ballot access requirements. Although each of these reforms have been profusely discussed in every one of the countries involved, so far, they have not been ...
Scherlis Perel, Gerardo Ezequiel
core
The Ethical Aspect of the Relationship of the Individual and the State in the Libertarian Perspective of Murray N. Rothbard [PDF]
, 2014 On the grounds of the libertarian ethics presented by Murray N. Rothbard, the state is an institution which acts against individuals and whole societies.
Płaszczyca, Małgorzata
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
La experiencia de la pobreza y su impacto en la organización popular de la ciudad de Lima
América Latina Hoy, 2009 RESUMEN: Con base en una investigación empírica realizada con técnicas cualitativas, se analiza la formación de organizaciones y acción colectiva en distintos tipos de estratos sociales en la ciudad de Lima.
María Ángeles LÓPEZ JIMÉNEZ
doaj +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Acta Universitatis Wratislaviensis. Anglica WratislaviensiaThis paper explores the implicit role of companionship in Kazuo Ishiguro’s Klara and the Sun (2021) by examining the bond between two technologically marginalized characters: Klara, an outdated Artificial Friend, and Rick, an “unlifted” boy who has not ...
Yiqun Xiao
doaj +1 more source
Resilience and vulnerability of Ukrainians: The role of family during the war [PDF]
Problems and Perspectives in ManagementThe full-scale russian invasion of Ukraine led to numerous physical and moral challenges. The paper aims to estimate the role of family as a social resilience driver in managing wartime challenges on a regional level.
Andriana Kostenko +5 more
doaj +1 more source