Results 61 to 70 of about 1,639 (298)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Disadvantaged yet Dignified: Reaffirming Humanity through Companionship in Kazuo Ishiguro’s “Klara and the Sun”

Acta Universitatis Wratislaviensis. Anglica Wratislaviensia
This paper explores the implicit role of companionship in Kazuo Ishiguro’s Klara and the Sun (2021) by examining the bond between two technologically marginalized characters: Klara, an outdated Artificial Friend, and Rick, an “unlifted” boy who has not ...
Yiqun Xiao
doaj   +1 more source

Resilience and vulnerability of Ukrainians: The role of family during the war [PDF]

Problems and Perspectives in Management
The full-scale russian invasion of Ukraine led to numerous physical and moral challenges. The paper aims to estimate the role of family as a social resilience driver in managing wartime challenges on a regional level.
Andriana Kostenko, Volodymyr Semenov, Oksana Osetrova, Oleksandr Kubatko, Mykola Nazarov, Vitalii Stepanov   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Ambiguous Public Space Towards Social Sustainability in Madurese Urban Kampong

, 2016
The public space is a social capital and it becomes an important part of society, which can promote social cohesion and prevent further fragmentation and atomization of the society (Madanipour, 2003).
Navastara, Ardy Maulidy, Pradinie, Karina, Martha, K.D. Erli   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

NETWORK CHARACTER OF INTERNATIONAL TERRORISM AND THE POSSIBILITY OF THE CONSOLIDATION OF THE RUSSIAN SOCIETY

Vestnik RUDN. International Relations, 2017
The purpose of this article is to analyze the network of the mechanism of reproduction of international terrorism - the phenomenon of post-truth, strongly modifies the previous interpretation of the political, ethnic, religious, cultural and social ...
А В Абрамов, С Н Федорченко, К П Курылев   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Analisis Dampak Kegiatan Industri Rokok Elektrik PT. Atomization Technology Terhadap Masyarakat Desa Purwosari

This research was to analyze the impact of the activities of the electronic cigarette industry PT. Atomization Technology Indonesia on the social, economic and public health conditions of the Purwosari village comunity, Pasuruan Regency.
Hariani, Ermatry, Widyawati, Retno Febriyastuti, Firmansyah, Mochammad Fikri   +2 more
core   +1 more source