Results 61 to 70 of about 13,064 (306)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

What does Marx mean by the "fetishism of commodities" ? [PDF]

open access: yes, 2010
The present paper aims to analyse Marx’s concept of “fetishism of commodities” by explaining the mechanism of a social genesis of determined illusions, arising in the sphere of production and circulation of commodities.
Dobra, Alexandra
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

NETWORK CHARACTER OF INTERNATIONAL TERRORISM AND THE POSSIBILITY OF THE CONSOLIDATION OF THE RUSSIAN SOCIETY

open access: yesVestnik RUDN. International Relations, 2017
The purpose of this article is to analyze the network of the mechanism of reproduction of international terrorism - the phenomenon of post-truth, strongly modifies the previous interpretation of the political, ethnic, religious, cultural and social ...
А В Абрамов   +2 more
doaj   +1 more source

State of the Industry 4.0 in the Andalusian food sector [PDF]

open access: yes, 2017
The food industry is a key issue in the economic structure of Andalusia, due to both the weight and position of this industry in the economy and its advantages and potentials. The term Industry 4.0 carries many meanings.
Córdoba-Roldán, Antonio   +3 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Library as Agent of [Re]Contextualization [PDF]

open access: yes, 1997
Paper presented at the Digital Humanities 2009 conference in College Park ...
Zafrin, Vika   +2 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

The Role of the Value Basis in the Context of Waging Non-Kinetic Wars: Methodological Prerequisites for Analysis

open access: yesRUDN Journal of Political Science
The relevance of the topic presented in the article is determined primarily by the current foreign policy situation, namely the hybrid war unleashed by the collective West against the Russian Federation, a significant component of which are the so-called
Alexander V. Kurochkin
doaj   +1 more source

Leadership: A critical text [PDF]

open access: yes, 2007
Providing a critical review and analysis of the key debates within leadership, this book challenges the notion of the individual or hero leader. The author develops the idea of leadership as a distributed process between lots of agents in an organization.
Western, Simon
core   +1 more source

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