Results 61 to 70 of about 11,733,884 (255)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Repression in Disguise: Effects of Covert Repression on the Erosion of Social Movements in Post-Indignados Madrid

Partecipazione e Conflitto
The growing securitization and criminalization of social movements in Europe raise concerns about the erosion of public freedoms. Yet scholarship often emphasizes overt repression, neglecting the effects of more covert strategies.
Mert Arslanalp, Gomer Betancor Nuez
doaj   +1 more source

From crisis to comfort : contemporary bestsellers and the French Middlebrow’s narrative of recovery

Belphégor, 2017
The present article proposes an account of the contemporary French Middlebrow through the study of a corpus of bestselling novels. I identify a recurring motif in the bestsellers of the Sarkozy years (2007-2012), a political period marked by debates on ...
Annamma Varghese
doaj   +1 more source

Numerical simulation of primary atomization: Interaction with experimental analysis

, 2013
This paper focuses on recent developments in numerical simulations and experimental techniques applied to jet atomization. Interface tracking based on coupled level-set, VOF, and ghost fluid approaches is presented, together with experimental methods ...
Rozé, C., Doring, M.,, Berlemont, Alain,, Doring, M., Dumouchel, C.,, Desjonqueres, P.,, Lounnaci, K.,, Leboucher, N., Vaudor, G., Vaudor, G.,, Leboucher, Nicolas, Ménard, T., M\ue9nard, T., Bouali, Z., Leboucher, N.,, Bouali, Zakaria, Cousin, J.,, Rozé, C.,, Sedarsky, David, Bouali, Z.,, Ménard, Thibaut, Ménard, T.,, Blaisot, J.B., Lounnaci, K., Idlahcen, S., Roz\ue9, C., Desjonqueres, P., Cousin, J., Blaisot, Jean, Cousin, Jean, Idlahcen, S.,, Sedarsky, David,, Dumouchel, C., Rozé, Claude, Dumouchel, Christophe, Blaisot, J.B.,, Berlemont, Alain   +36 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Towards Resolving the Atomization Process of an Idealized Fire Sprinkler with VOF Modeling [PDF]

, 2017
[EN] Fire suppression modeling depends on accurate characterization of the atomization processes of fire sprinklers. Numerical modeling, particularly the volume of fluid (VOF) method, has been applied to understanding the atomization behavior of an ...
Karl, Meredith, Wang, Y., Karl Virgil Meredith, Y. Wang, X. Zhou, Zhou, X.   +5 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Diesel spray atomization model considering nozzle exit turbulence conditions

, 2019
Art atomization model for plain-orifice diesel fuel sprays is developed. It considers both turbulent fluctuation in the jet flow and wave growth by gas inertia force due to the jet velocity. The atomization model developed is implemented as a module into
Koo, JY, Lee, EJ, Huh, KY
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Disadvantaged yet Dignified: Reaffirming Humanity through Companionship in Kazuo Ishiguro’s “Klara and the Sun”

Acta Universitatis Wratislaviensis. Anglica Wratislaviensia
This paper explores the implicit role of companionship in Kazuo Ishiguro’s Klara and the Sun (2021) by examining the bond between two technologically marginalized characters: Klara, an outdated Artificial Friend, and Rick, an “unlifted” boy who has not ...
Yiqun Xiao
doaj   +1 more source