Results 121 to 130 of about 7,401,341 (346)
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
ReligionsThe worldwide launch of neoliberalism ushered everyone into an atomized society. Neoliberalism transforms Homo sapiens into Homo economicus, a narcissistic self-entrepreneur that positions their body as a factory, skills as resources, and earnings as ...
Yulong Li, Zhen Chen
doaj +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Anarchy, State, and Dystopia: Venezuelan Economic Institutions before the Advent of Oil. [PDF]
This paper studies the evolution of Venezuelan economic institutions before the emergence of oil exploitation in 1920. We argue that by 1920 Venezuela had developed a highly centralized state and a professionalized military.
Adam J. Gomolin, Francisco Rodríguez
core
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Neo-liberalism, consequences on the prospect of democratization in Latin America [PDF]
The present paper aims to analyze the consequences of neo-liberalism on the prospect of democratization in Latin America, by concentrating on two case-studies, Brazil and Chile. The analysis is done on a double level.
Dobra, Alexandra
core +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Family leisure facilities as a driver of city development
Urbis et Orbis: Mikroistoriâ i Semiotika GorodaThe study examines the issue of developing family leisure facilities within the context of urban space management. The relevance of this problem lies in research indicating that families engaged in family leisure activities tend to be stronger ...
Oksana Gomazova +2 more
doaj +1 more source
Is Liberalism the Problem? Review of Patrick Deneen, Why Liberalism Failed
, 2018 A specter is haunting conservatism — the specter, indeed, of Marx. Those conservatives too young to remember the Cold War are increasingly suspicious of the economic and political prescriptions of the older anticommunism: capitalism as opposed to ...
McCullough, Ross W.
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source