Results 91 to 100 of about 290,839 (347)

Social Impact Bonds

open access: yes, 2015
Vor rund fünf Jahren wurde in Grossbritannien der weltweit erste Social Impact Bond (SIB) und damit ein neuartiges, innovatives Finanzierungsinstrument lanciert. Dieser pay for success-Kontrakt hat sogleich für hohe mediale Aufmerksamkeit gesorgt. Bislang wurden SIBs vor allem im angelsächsischen Raum aufgelegt.
von Schnurbein, Georg   +2 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Fighting Mobile Phone Addiction with Forgiveness Following Interpersonal Transgressions: A Psychological Compensation Perspective

open access: yesBehavioral Sciences
Current research on addressing mobile phone addiction primarily focuses on mitigating the influence of psychopathological factors. In the present work, we conducted three studies to investigate a novel hypothesis that forgiveness, as a form of ...
Gang Du, Xiaogang Wang
doaj   +1 more source

Networking for Philanthropy: Increasing Volunteer Behavior via Social Networking Sites [PDF]

open access: yes, 2014
Social networking sites (SNSs) provide a unique social venue to engage the young generation in philanthropy through their networking capabilities. An integrated model that incorporates social capital into the Theory of Reasoned Action is developed to ...
Kim, Yoojung, Lee, Wei-Na
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Love Thy Neighbor: Bonding versus Bridging Trust [PDF]

open access: yes
We study how trust is generated in society. In a two-sector model, we analyze two communities. In the bonding community people do not trust people outside their regular networks.
Poulsen, Odile, Svendsen, Gert Tinggaard
core  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz   +3 more
wiley   +1 more source

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