Results 81 to 90 of about 21,702,173 (276)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Juvenile Hackers: An Empirical Test of Self-Control Theory and Social Bonding Theory
International journal of cybersecurity intelligence and cybercrime, 2018 In accordance with a similar growth in information technology, computer hacking has become a pervasive issue as a form of crime worldwide in recent years.
S. back, Sadhika Soor, J. LaPrade
semanticscholar +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Playfulness causes meaningful wellbeing: an investigation of 125 global playful memories
Frontiers in PsychologyThe role of playfulness for wellbeing has a critical and diverse relationship. In past theoretical works, playfulness as a broad concept has been studied as causing broad wellbeing meanings.
Leland Masek
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Impact of group dancing during Japanese festivals on people’s sense of community
Frontiers in PsychologyMoving together or attending festivals has been reported to foster social bonding. However, whether festivals with and without dancing affect individuals’ social bonds and sense of community remains unclear.
Satoshi Kawase, Kei Eguchi
doaj +1 more source
Brazil's football warriors: Social bonding and inter-group violence
Evolution and human behavior, 2018 Football-related violence (hooliganism) is a global problem. Previous work has proposed that hooliganism is an expression of social maladjustment. Here we test an alternative hypothesis, that hooliganism is typically motivated by a parochial form of ...
M. Newson +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
How to make head or tail of bridging and bonding? Adressing the methodological ambiguity [PDF]
A distinction has recently been proposed between bridging (or encompassing) and bonding (or inward-looking) social networks. However, existing theoretical contributions remain vague as to the fundamental meaning of both concepts.
Geys, Benny
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source