Results 91 to 100 of about 5,599,195 (302)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Factor structure and construct validity of the Adult Social Care Outcomes Toolkit for Carers (ASCOT-Carer) [PDF]

, 2015
Background: The ASCOT-Carer is a self-report instrument designed to measure social care-related quality of life (SCRQoL). This article presents the psychometric testing and validation of the ASCOT-Carer four response-level interview (INT4) in a sample of
A Bowling, A Camden, AK Ekwall, Ann P. Netten, AP Netten, B Robinson, B Schoenmakers, C Cohen, C Mockford, C Quinn, C Quinn, CL White, D Potoglou, Department of Health, Department of Health, Department of Health, Department of Health, DL Streiner, E Courtin, E Moniz-Cook, ETP Heuvel Van den, G Willis, GJ Molloy, H Al-Janabi, H Al-Janabi, J Cortina, J Harden, J Malley, JE Gaugler, JN Morris, Julien E. Forder, Juliette N. Malley, K Harvey, L Cronbach, L Cronbach, L Hu, L Kitrungrote, LP McKeown, M Evans, M Hughes, M Naiditch, MI Zegwaard, N Greenwood, OECD, PL Hudson, R Brooks, R Romero-Moreno, R Schulz, R Schulz, RB Kline, RD Hays, S Bridges, S Rand, S Sorensen, SI Reed, Stacey E. Rand, The EuroQol Group, U Stenberg   +57 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Latina Women in the United States: Child Care Preferences and Arrangements [PDF]

, 2017
Formal child care has been associated with myriad benefits for children, such as improvements in cognitive development and language skills. Immigrant children may derive unique benefits from formal child care, as research has also confirmed that center ...
Banik, Rumeli, Ph.D., Roubeni, Sonia, M.A., Satkowski, Laura, Ph.D.   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Crossing the paradigm of 'Including the "Self"': toward an understanding of comprehensive reflexivity and a systemic epistemology as useful concepts for social care professionals

Scottish Journal of Residential Child Care, 2020
Sometimes the most important relationships in a young person's life are those with the social care professionals who are charged with their care. Often these relationships develop and evolve within complex systems with an increasing move toward a culture
Niall Reynolds
doaj   +1 more source

In response to the Health Secretary Jeremy Hunt's plans for a safer 7 day dementia service [PDF]

, 2016
Jeremy Hunt's recent announcement for a safer 7 day dementia service outlines some basic principles to improve dementia care, none of which are new, but are these principles realistic in the current climate of the NHS and does it address the real issues ...
Brooke, Joanne
core