Results 101 to 110 of about 1,940,859 (305)

Using a ‘wellbeing’ cost-effectiveness approach to improve resource allocation in social care [PDF]

, 2015
The promotion of wellbeing is the newly-stated guiding principle for the long-term care (social care) system in England. It signals a shift away from a focus on care need ‘deficits’ approach.
Fernández, José-Luis, Forder, Julien E.   +1 more
core  

Understanding and using experiences of social care to guide service improvements:translating a co-design approach from health to social care [PDF]

Background Local authorities need to find new ways of collecting and using data on social care users’ experiences to improve service design and quality.
Maddison, Jane Ridley, Maddison, Jane, Wilberforce, Mark Robson, Morrissey, Emmie, Birks, Yvonne, Birks, Yvonne Frances, Martin, Angela, Lambat, Ahmed, Bebbington, P, Locock, Louise, Ryan, Sara, Bebbington, Pam, Ziebland, Sue, Robson, Louise, Wilberforce, Mark, Baxter, Kate   +15 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A social marketing perspective of young people’s sexual health

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityBACGROUND:Unintended pregnancy and sexually transmitted infections among young people are priority public health issues in the UK.
Wakhisi, Anthony Simiyu
core  

Care poverty and conflicts in social citizenship: the right to care? [PDF]

This chapter places the theory of care poverty in the context of other theories of care and provides an overview of the conflicts inherent in these theories, including the idea of ‘social citizenship’ – the right to access resources to meet needs, in ...
Rummery, Kirstein
core   +1 more source

Crossing the paradigm of 'Including the "Self"': toward an understanding of comprehensive reflexivity and a systemic epistemology as useful concepts for social care professionals

Scottish Journal of Residential Child Care, 2020
Sometimes the most important relationships in a young person's life are those with the social care professionals who are charged with their care. Often these relationships develop and evolve within complex systems with an increasing move toward a culture
Niall Reynolds
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Statutory registration awareness amongst social care workers

, 2018
Statutory registration for health and social care professionals has become an increasing feature of regulatory systems in many nations (Allsop & Saks, 2002; Cornes, Manthrope, Huxley & Sherrill, 2007; Byrne, 2016).
Power, Martin, D’Arcy, Patricia
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source