Results 101 to 110 of about 5,599,195 (302)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Creating Excellence in Dementia Care: A Research Review for Ireland's National Dementia Strategy [PDF]
, 2012 Examines the prevalence and economic and social costs of dementia; policies, practices, and data on health and social care services in community-based, acute care, and long-term residential settings; and proposed elements for a new ...
Eamon O'Shea +2 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
‘Low-Level’ Social Care Needs of Adults in Prison (LOSCIP): A Scoping Review of the UK Literature
Social SciencesIn England, local authorities are responsible for providing social care in prison in accordance with the Care Act (implemented in 2015), but little is known about ‘low-level’ needs that do not meet eligibility criteria.
Deborah Buck +11 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The value of resilience as a concept for practice in residential settings
Scottish Journal of Residential Child Care, 2003 Resilience is a concept that is increasingly gaining currency as a basis for practice with children and young people. The concept, however, is not easy to define and the term is often used loosely or uncritically so that the implications for practice are
Brigid Daniel
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Nurturing group work in a children's home
Scottish Journal of Residential Child Care, 2003 This paper describes a joint Education, Social Services and Health initiative which introduced the Family Links Nurturing Programme in a Sunderland Children's Home.
Maggie Bell +3 more
doaj +1 more source