Results 111 to 120 of about 5,599,195 (302)

Social wealth and optimal care [PDF]

open access: yes
Many accidents result in losses that cannot be perfectly compensated by a monetary payment. Moreover, often injurers control the magnitude rather than the probability of accidents.
Darri-Mattiacci, Giuseppe   +1 more
core   +1 more source

Adult social care: is privatisation irreversible? [PDF]

open access: yes, 2018
The privatisation of adult social care is a 30-year process that has grown unchecked, made worse by austerity politics. Should the private sector lose interest and leave the market, the consequences will be grave. Bob Hudson writes that, whilst it is not
Hudson, Bob
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Guest Editorial Vol2 no2

open access: yesScottish Journal of Residential Child Care, 2003
After just over 3 years as Director of the Scottish Institute for Residential Child Care (SIRCC), I am returning to work in the Social Work Services Inspectorate. This has caused me to reflect on whether anything has changed in residential care over that
Kirstie Maclean
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Three strong women: from care to university

open access: yesScottish Journal of Residential Child Care, 2005
Poor educational 'outcomes' of looked after children have been a matter of increasing concern. This article explores some of the factors that might make for educational success by looking at the experiences of three young women who have been in care in ...
Ian Milligan
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

A Review of the Healthcare and Social Care Needs of the Older Prisoner Population in England and Wales

open access: yesSocial Sciences
In recent years, research on older prisoners in England and Wales has expanded significantly, and the term “older prisoner” is now well entrenched in the prison-based literature.
Paul Gavin   +2 more
doaj   +1 more source

Residential care for elderly people: policy implications from an exploratory study

open access: yes, 1997
The Association of Directors of Social Services, in response to the Burgner review, has called for joint health and local-authority inspection of residential homes (Community Care, 8.1.97, p. 1). Yet there is little agreement about what constitutes good
Abbey, Alison   +10 more
core  

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