Results 131 to 140 of about 1,940,859 (305)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Social Care Research in Action – An ‘unconference’ at the LSE on 19 October 2012
, 2012 Social care practitioners are keen to influence the research agenda but also want help and guidance on how to access and implement its findings; researchers want to understand how their work could better influence the decision-making processes in social ...
Blog Editor, Social Care Evidence in Practice
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Blackburn with Darwen Borough Council - improving efficiency and outcomes through telehealthcare
International Journal of Integrated Care, 2013 Claire Smith, Stephen Tingle
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This study was a qualitative examination of patient and staff experiences within a redeveloping acute NHS hospital Trust in England.
Pajak, Sarah
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Technique for improving care integration models [PDF]
, 2011 Recent developments in technologies and improved life style have had a positive impact on prolonging human life contributing to the increasing elderly population. As a consequence, many countries (particularly developed ones) started to experience higher
Zulkepli, J, Eldabi, T
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Towards a collaborative model of integrated care in Tona
International Journal of Integrated Care, 2014 Ester Sarquella +2 more
doaj +1 more source