Results 141 to 150 of about 16,927,067 (395)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Crossing the paradigm of 'Including the "Self"': toward an understanding of comprehensive reflexivity and a systemic epistemology as useful concepts for social care professionals

open access: yesScottish Journal of Residential Child Care, 2020
Sometimes the most important relationships in a young person's life are those with the social care professionals who are charged with their care. Often these relationships develop and evolve within complex systems with an increasing move toward a culture
Niall Reynolds
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Dispositivos institucionais filantrópicos e socioeducativos de atenção à infância na assistência social

open access: yesEstudos de Psicologia (Campinas)
Estudou-se a Assistência Social como instituição que faz dispositivos de produção de subjetividade na atenção à criança e ao adolescente. Para tanto, utilizaram-se algumas coordenadas analíticas conjunturais e estruturais para mapear modelos de atenção ...
Silvio José Benelli   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Exploring the Link Between Customer Care and Brand Reputation in the Age of Social Media [PDF]

open access: yes, 2008
Consumers are more empowered than ever to share their customer care experiences. Through the use of social media and new communications tools and technologies, messages can be sent more widely than ever before.
Francois Gossieaux   +4 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

‘Low-Level’ Social Care Needs of Adults in Prison (LOSCIP): A Scoping Review of the UK Literature

open access: yesSocial Sciences
In England, local authorities are responsible for providing social care in prison in accordance with the Care Act (implemented in 2015), but little is known about ‘low-level’ needs that do not meet eligibility criteria.
Deborah Buck   +11 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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