Results 81 to 90 of about 20,716,741 (337)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Journal of Integrative Environmental Sciences, 2019 The paper covers the public debate on BECCS (bioenergy with carbon capture and storage) between 2008 and 2018. Through a qualitative analysis of around 800 feature articles, editorials, and opinion pieces published in English, German, Swedish, Danish ...
Simon Haikola +2 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Blogs as Elusive Ethnographic Texts
International Journal of Qualitative Methods, 2017 Burgeoning online environments offer completely new opportunities for ethnographic and other forms of qualitative research. Yet there are no clear standards for how we study online texts from an ethnographic perspective.
Liza C. Kurtz +4 more
doaj +1 more source
Low-carbon innovation policy with the use of biorenewables in the transport sector until 2030
Apstract: Applied Studies in Agribusiness and Commerce, 2015 The topic of the present study deals with the changes and future trends of the European Union’s climate policy. In addition, it studies the manner in which Hungary’s transport sector contributes to the success of the above.
Csaba Fogarassy +3 more
doaj +1 more source
, 2015 In the context of seemingly intractable social challenges such as climate change, environmental destruction, youth unemployment and social exclusion, social innovation has emerged as a potentially sustainable solution.
Jürgen Howaldt, Ralf Kopp, M. Schwarz
semanticscholar +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Urban Planning, 2019 As the growing number of older people, particularly in urban areas, and changing lifestyles are increasing the importance of continuing to live in the community (ageing in place), studies show that age-related planning of living environments is often ...
Carlo Fabian +5 more
doaj +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source