Results 31 to 40 of about 63,874 (260)

Social hierarchies and meritocracy: objective status and the moderating role of subjective social status on perceived meritocracy

Frontiers in Sociology
This study investigates how subjective and objective dimensions of social status shape perceptions of meritocracy within Chile’s highly unequal society.
Julio Iturra-Sanhueza, Juan C. Castillo, Juan C. Castillo, Juan Diego García-Castro, Juan Diego García-Castro   +4 more
doaj   +1 more source

Barriers in Achieving Social Cohesion: A Qualitative Study

Journal of Economy Culture and Society, 2021
Turkey currently has a large number of asylum applications from asylum seekers demanding international protection and expecting to move on to third countries. The number of asylum seekers in Turkey increased dramatically following the mass immigration of
Edip Aygüler, Sema Buz, Bekir Güzel
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Trust and compliance: Milieu-specific differences in social cohesion during the COVID-19 pandemic in Germany

Frontiers in Sociology, 2022
As a response to the COVID-19 pandemic, an increase in social cohesion was observed during the first wave and its aftermath. A closer look reveals heterogeneous responses regarding aspects of cohesion—such as trust in others and compliance with ...
Tim Schröder, Anne Speer, Patrick Sachweh, Olaf Groh-Samberg   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Fear of the Family. Barbara Lüthi in Conversation with Lauren Stokes

Österreichische Zeitschrift für Geschichtswissenschaften
Talk with Lauren Stokes, historian at Northwestern University (Illinois), about her book "Fear of the Family, Guest Workers and Family Migration in the Federal Republic of Germany" (Oxford University Press 2022).
Barbara Lüthi, Lauren Stokes
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Navigating Conflicting Interests: The Role of Gender Competent Management for Effective Gender Equality Plans

Social Inclusion
The Horizon Europe mandate requiring Gender Equality Plans (GEPs) for funding eligibility has initiated a veritable wave of documented initiatives across research performing organisations (RPOs).
Angela Wroblewski, Karin Grasenick
doaj   +1 more source