Results 51 to 60 of about 253,410 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Growing decision-making: the role of theory of mind, empathy, and personality traits in school-age children

Frontiers in Psychology
Children’s decision-making is a socio-cognitive skill embedded within a broader system that promotes understanding of others and effective management of interpersonal contexts, making it closely linked to Theory of Mind (ToM) and empathy.
Elisabetta Lombardi, Cinzia Di Dio, Ilaria Castelli, Davide Massaro, Antonella Marchetti, Annalisa Valle   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhancing Social Entrepreneurial Competence Amongst University Students: A Social Entrepreneurship Pedagogical Model in Hong Kong

, 2023
This study examines the effectiveness of a social entrepreneurship education model in Hong Kong on enhancing students’ social entrepreneurial competence, comprising their knowledge, behaviours, and social entrepreneurial intentions. The pedagogical model
Lai, Shu Ning, Chui, Cheryl Hiu-kwan, Fung, Sammy Lai Kin, PENG, Shiqi   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analogue Strategies and a Sense of Humour in the Learning of Social Competence on the Part of Social Education Professionals [PDF]

, 2013
In this article we explore the development and initial results of an innovative methodology that uses metaphor and the participants’ sense of humour to create a narrative space in the context of university training in social competence that facilitates ...
Rosa i Gregori, Genoveva, López, Paco, Navarro-Segura, Lisette   +2 more
core  

Post-simulation debriefing as a stepping stone to self-reflection and increased awareness — a qualitative study

Advances in Simulation
Background The voice of the students should be engaged in simulation curriculum development. Involving the students in the development of debriefing strategies might result in a deeper understanding of learning. However, few studies have investigated the
Sissel Eikeland Husebø, Inger Åse Reierson, Anette Hansen, Hilde Solli   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Unpacking Theory of Mind in developmental coordination disorder: the role of manual dexterity and perspective-taking

Frontiers in Psychology
Developmental Coordination Disorder (DCD) has often been associated with challenges in social functioning, but it remains unclear whether these reflect a generalized impairment in Theory of Mind (ToM) or selective vulnerabilities related to motor and ...
F. Manzi, F. Manzi, F. Manzi, G. Purpura, G. Purpura, G. Peretti, G. Peretti, V. Di Giusto, V. Caravella, D. Massaro, A. Marchetti, A. Cavallini   +11 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source