Results 141 to 150 of about 19,192,322 (351)

Editorial: Caregivers of older individuals: reflections about living, health, work and social conditions. [PDF]

Front Med (Lausanne), 2023
Nunes DP, Dos Santos-Orlandi AA, Brito TRP.   +2 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Determinantes sociales de la salud y discapacidad: caso Santiago de Cali / Social determinants of health and disability: the Santiago de Cali case

Revista Facultad Nacional de Salud Pública, 2013
Objetivo: establecer la relación entre los determinantes sociales de la salud y la discapacidad en Santiago de Cali. Metodología: estudio descriptivo correlacional.
Consuelo Vélez A, José A. Vidarte , Julián D. Cerón B   +2 more
doaj  

Social conditions as fundamental causes of disease.

Journal of Health and Social Behavior, 1995
Bruce G. Link, J. Phelan
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Alaska Review of Social and Economic Conditions Vol. 32, No. 1

, 2000
When the U.S. bought Alaska in 1867, it acquired an area twice the size of the 13 original American colonies and three quarters as big as the Louisiana Purchase.
Hull, Teresa, Leask, Linda
core  

Making Social Work Work: Improving social work for vulnerable families and children without parental care around the world: A literature review [PDF]

, 2012
This literature review calls for families and children in developing countries to be supported in ways that are appropriate to the conditions, culture and resources available rather than through approaches to social work that are common in the west ...
Andy Bilson, Joanne Westwood, Westwood, Joanne Louise, Bilson, Andy, Westwood, Joanne   +4 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Lifestyles: from the individual to the context

Revista Facultad Nacional de Salud Pública, 2012
Lifestyles have been studied by different disciplines such associology, anthropology, and epidemiology. Both the termand the greatest developments in this regard stem from thesocial and cultural sciences, which consider lifestyles as groupbehavior ...
Luz S. Álvarez C.
doaj