Results 121 to 130 of about 20,042,590 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Lifestyles: from the individual to the context

Revista Facultad Nacional de Salud Pública, 2012
Lifestyles have been studied by different disciplines such associology, anthropology, and epidemiology. Both the termand the greatest developments in this regard stem from thesocial and cultural sciences, which consider lifestyles as groupbehavior ...
Luz S. Álvarez C.
doaj  

Meteorological and social conditions contribute to infectious diarrhea in China. [PDF]

Sci Rep, 2021
Yang X, Xiong W, Huang T, He J.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gestational Malaria and Living Conditions in Turbo, Colombia

Social Medicine, 2011
Background: The study of gestational malaria has focused on biomedical aspects and ignored social aspects. Objectives: To describe the socio-economic characteristics of families with and without gestational malaria in Turbo (Antioquia, Colombia ...
Jaime Carmona-Fonseca, María Mercedes Arias V., Adriana Correa B., Maritza Lemos C.   +3 more
doaj  

Reflections on major epidemics in history reported by online English news media and literature: interaction between epidemics and social conditions. [PDF]

Front Public Health, 2023
Chen X, Wei X, Zhang Y, Sun Y, Xu Z, Zhang S, Li L.   +6 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Human social conditions predict the risk of exposure to zoonotic parasites in companion animals in East and Southeast Asia. [PDF]

Commun Med (Lond), 2022
Colella V, Wongnak P, Tsai YL, Nguyen VL, Tan DY, Tong KBY, Lu N, Fang F, Zhijuan Y, Wang J, Liu X, Dong J, Nurcahyo W, Hadi UK, Venturina V, Taweethavonsawat P, Tiwananthagorn S, Le TQ, Bui KL, Watanabe M, Rani PAMA, Traub RJ, Beugnet F, Chalvet-Monfray K, Halos L.   +24 more
europepmc   +1 more source

Musée social.

, 1896
Title from caption.Mode of access ...
Musée social (Paris, France)
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source