Results 121 to 130 of about 19,192,322 (351)
Neuroscience and Biobehavioral Reviews, 2018 HighlightsSocial cognitive deficits are present in a wide range of clinical conditions.These are comparable in magnitude to more established neurocognitive deficits.Social cognitive deficits appear to hold both functional and clinical relevance.These are
Jack Cotter +5 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Obesity as a chronic care challenge: new opportunities for social work practice
, 2020 While perhaps not garnering the attention of conditions like cancer or heart disease, or behavioral health conditions such as addiction and mental illness, obesity is emerging as a major health concern across the globe.
Kincaid, Zoraida, Sullivan, Patrick
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Revista Latino-Americana de Enfermagem, 2008 Adolescent maternity involves relevant factors associated with each family, culture and society. This research aimed to describe the experiences in the trajectory of adolescent maternity.
Luiza Akiko Komura Hoga
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Socially just social capital : do we assume too much?
, 2005 The confusion which accompanies the definition, meaning and measurement of social capital does not appear to have affected the enthusiasm with which it has been taken up by scholars, policy makers and social commentators.
Bolzan, Natalie
core
BMC Geriatrics, 2018 BackgroundAs the population is aging, the number of persons living with multiple chronic conditions (MCC) is expected to increase. This review seeks to answer two research questions from the perspectives of older adults with MCC, their caregivers and ...
K. McGilton +19 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
RUDN Journal of Ecology and Life Safety, 2012 In article empirical results of scientific research of social and psychological criteria of adaptation of nonresident students of I and III courses of Ecological Faculty of PFUR at the age from 18—21 are presented.
Ya V Kuzmina
doaj