Results 131 to 140 of about 6,200,273 (303)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Effects of Stress on Glycemic Control Brought on by Changes in Social Conditions Due to COVID-19. [PDF]

Intern Med, 2021
Masuda M, Tomonaga O.
europepmc   +1 more source

A topological approach to the Arrow impossibility theorem when individual preferences are weak orders (forcoming in ``Applied Mathematics and Compuation''(Elsevier)) [PDF]

We will present a topological approach to the Arrow impossibility theorem of social choice theory that there exists no binary social choice rule (which we will call a social welfare function) which satisfies the conditions of transitivity, independence ...
Yasuhito Tanaka
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A scenario-based sustainable dual-channel closed-loop supply chain design with pickup and delivery considering social conditions in a natural disaster under uncertainty: a real-life case study. [PDF]

Environ Dev Sustain, 2023
Taherifar M, Hasani N, Zokaee M, Aghsami A, Jolai F.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Representações sociais sobre famílias em situação de vulnerabilidade: uma revisão da literatura [Social representations of families in vulnerable conditions: a literature review]

Revista Enfermagem UERJ, 2015
A família é influenciada por fatores de ordem social, cultural, econômica, política, determinando transformações em sua configuração e dinâmica.
Joana Iabrudi Carinhanha, Lucia Helena Garcia Penna, Denize Cristina de Oliveira   +2 more
doaj  

Necessary and sufficient conditions for a resolution of the social choice paradox [PDF]

We present a restriction on the domain of individual preferences that is both necessary and sufficient for the existence of a social choice rule that is continuous, anonymous, and respects unanimity.
Chichilnisky, Graciela, Heal, Geoffrey
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Issues of scale in the global accreditation of sustainable tourism: schemes toward harmonized re-embeddedness?

Sustainability: Science, Practice, & Policy, 2012
In efforts to find synergies or, conversely, tradeoffs between the environmental and social pillars of sustainable development policies, geographical scale is often an important issue.
Mikael Klintman
doaj