Results 101 to 110 of about 3,227,851 (305)

Annual Report for the Construction Industry Progress Fund and the Associated General Contractors of Alaska [PDF]

open access: yes, 2013
The Construction Industry Progress Fund (CIPF) and the Associated General Contractors (AGC) of Alaska are pleased to have produced another edition of “Alaska’s Construction Spending Forecast.” Compiled and written by Scott Goldsmith and Mouhcine ...
Goldsmith, Oliver Scott   +1 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Social constructions of successful ageing: the case of Ruware Park in Marondera, Zimbabwe

open access: yesSocial Work/Maatskaplike Werk, 2019
Social constructions of successful ageing provide an invaluable resource for challenging and reconfiguring approaches and models of geriatric care. This paper has established that contrary to normative framing of successful ageing as that (ageing) which ...
Mbulayi, Shingirai Paul   +1 more
doaj   +1 more source

The social construction of educational technology through the use of proprietary software [PDF]

open access: yes, 2010
Major strands of science and technology studies (STS) in recent decades have been the 'social shaping of technology' (SST) and 'social construction of technology' (SCOT) movements, whose adherents maintain that technological systems are determined just ...
Bissell, Christopher
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Social Construction: Understanding Construction in a Human Context [PDF]

open access: yes
As lean construction has evolved as a practice, efforts have been made to develop theoretical foundations for understanding it. These efforts have been informed by our understanding of lean manufacturing, a source of many of the seminal ideas for lean ...
Howell, Gregory   +3 more
core  

The social construction of meaning : Reading Animal Farm in the classroom [PDF]

open access: yes, 2013
The novel, it has generally been assumed, was from its very beginnings a literary form designed to be read by solitary, silent individuals. One consequence of this assumption is that the class novel, read amid all the noise and sociality of the classroom,
Yandell, John
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

The Social Construction of Successful Market Reforms [PDF]

open access: yes
The transition from socialism to capitalism has spawned a large literature on comparative policy reforms. While many sociologists using qualitative data have concluded that neo-liberal reforms led to negative outcomes, a large body of cross-national ...
David Stuckler   +2 more
core  

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