Results 91 to 100 of about 133,886 (308)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Research on Combined Construction Technology for Cross-Subway Tunnels in Underground Spaces

open access: yesEngineering, 2018
Given the increasingly notable segmentation of underground space by existing subway tunnels, it is difficult to effectively and adequately develop and utilize underground space in busy parts of a city.
Xiangsheng Chen
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Implementation of GPS controlled highway construction equipment. [PDF]

open access: yes
CMSC: 2006 WO 1.4dozers, motor graders, and excavators is quickly becoming common place in private sector construction because it speeds project delivery and cuts costs.
Vonderohe, Alan P.   +1 more
core  

The social procurement practices of tier-one construction contractors in Australia [PDF]

open access: yes, 2019
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Social procurement is becoming an increasingly important requirement in the delivery of private- and public- sector construction projects across the world, yet there is relatively ...
Loosemore, M, Reid, S
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

«Green» Technologies In The Construction Of Social Facilities

open access: yesProcedia Engineering, 2016
Abstract The article analyses the pattern of introduction of “green” technologies in the design and social sphere objects building. It is considered the issues of ecological-economic justification and effectiveness of “green” innovations in the social construction segment.
Izvekova, Oksana   +2 more
openaire   +1 more source

Social work as narrative: An investigation of the social and literary nature of social work accounting

open access: yes, 1993
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis investigates what can be gained by approaching social work reports and conversations as narratives.
Hall, Christopher J, Hall, C.J
core  

Safer construction : the development of a voluntary code of practice to improve safety performance in the Australian construction industry [PDF]

open access: yes, 2007
In Australia, between 1994 and 2000, 50 construction workers were killed each year as a result of their work, the industry fatality rate, at 10.4 per 100,000 persons, is similar to the national road toll fatality rate and the rate of serious injury is 50%
Godfrey, P, Lindgard, H
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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