Results 111 to 120 of about 134,426 (309)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Construction of sails for Open Day, 2013 [PDF]
, 2013 Construction of shade sails for Open Day 2013, Hawthorn Campus, 4 August 2013.
Swinburne University of Technology
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
View of construction on the AMDC, 2013 [PDF]
, 2013 View of construction on the Advanced Manufacturing and Design Centre (AMDC) from Burwood Road, Hawthorn Campus.
Swinburne University of Technology
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Perceptions of acculturation and social identity construction among three Taiwanese/Chinese migrants in Australia [PDF]
, 2009 In recent years, increasing numbers of Chinese migrants have come to Australia to study or to live. In doing so, they have entered a new cultural space. They are faced with many challenges, not only to do with study experience, workplace experience and
Lo, Shu-Fen (Michelle)
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A reflexive capability model for sustainable e-business environments in construction supply chain [PDF]
, 2006 Despite the increasing significance of e-business worldwide and construction market leaders developing innovative e-business applications, the widespread uptake in the Australian construction industry is lagging.
London, Kerry (R19003) +2 more
core
The impact of climate physical risk on smart agricultural production efficiency
Frontiers in Sustainable Food SystemsGlobal climate change is intensifying, while agriculture is undergoing rapid digital transformation. Against this background, Climate Physical Risk (CPR) has become an important exogenous shock affecting Smart Agricultural Production Efficiency (SAPE ...
Qian Zheng +6 more
doaj +1 more source