Results 141 to 150 of about 2,350,113 (312)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Folk Theory of Mind: Conceptual Foundations of Social Cognition [PDF]
, 2003 The human ability to represent, conceptualize, and reason about mind and behavior is one of the greatest achievements of human evolution and is made possible by a “folk theory of mind” — a sophisticated conceptual framework that relates different mental ...
Malle, Bertram F.
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
THE RELATIONSHIP BETWEEN WORK DEMANDS AND SOCIAL SUPPORT ON WORK STRESS DURING THE PANDEMIC
Journal of Vocational Health StudiesBackground: Stress is the effect of competition and high professional demands in the workplace. The Occupational Safety and Health Agency (UPT Keselamatan Kerja) is a technical implementation unit with responsibilities and functions in occupational ...
Nisrina Tiara Sani +2 more
doaj +1 more source
On the Link between Human Capital and Firm Performance. A Theoretical and Empirical Survey [PDF]
The present paper provides a review of the literature focusing the relationship between human capital and performance essentially at firm level. The exposition is approached in three different but interrelated perspectives: economic, technological and ...
Aurora Teixeira
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
OrganizacijaThe purpose of this study, guided by the Job Demands-Resources Model, is to investigate the role of workplace friendships in mitigating burnout. This research is notable for its unique focus on a relatively rare sample: social care leaders.
Schutzmann Réka +4 more
doaj +1 more source