Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Psychosocial job demands, organizational resources, and mental well-being in psychologists: factors associated with quality of work life. [PDF]
Crespo Castizo R +3 more
europepmc +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
A novel context-discrepancy assessment of impression management facets in autistic and non-autistic adults: an initial validation. [PDF]
Ai W, Yu JX, Jacob BK, Lai MC.
europepmc +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Longitudinal Associations Between Work-Related Factors and the Need for Recovery of Long-Term Care Workers. [PDF]
Dams LJJ, Heijkants CH, Boot CRL.
europepmc +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Are International Market Demands Compatible with Serving Domestic Social Needs? Challenges in Strengthening Innovation Capacity in Kenya's Horticulture Industry [PDF]
Agrifood stakeholders across the world are under ever-increasing pressure with globalization and new market demands, together with changing quality and safety requirements.
Dijkman, Jeroen +3 more
core
Decoding autonomy in digital work: how direct, indirect, and moderated effects shape health and burnout of social workers. [PDF]
Gnugesser E +3 more
europepmc +1 more source
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source

