Results 91 to 100 of about 655,003 (315)

Social differentiation in young people's political participation: the impact of social and educational factors on youth political engagement in Britain

open access: yes, 2014
Over the course of the last decade, policy makers in Britain have become increasingly concerned about the apparent and persisting withdrawal by young people from the formal political process.
Foard, N, Henn, M
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Sulfonylurea prescription patterns in elderly patients with type 2 diabetes mellitus: A comprehensive analysis of real‐world data from pharmacies in Japan

open access: yesJournal of Diabetes Investigation
Aims/Introduction The study aim was to investigate sulfonylurea prescription patterns in elderly patients (age ≥65 years) with type 2 diabetes mellitus in Japan. Sulfonylurea use among older adults has been insufficiently examined, despite the associated
Michiko Yamazaki   +6 more
doaj   +1 more source

Older men learning through religious and political affiliations: case studies from Malta

open access: yesAS: Andragoška Spoznanja, 2014
This article examines two case studies from Malta that focus on older men learning through informal channels. The first case study investigated the role of a community-based organisation - namely, a religious confraternity dedicated to 'Our Lady of ...
Marvin Formosa   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Cohabitation and social engagement

open access: yesCanadian Studies in Population, 2012
In Canada, nonmarital cohabitation has become a normative life experience, but there are uncertainties regarding its contribution to social cohesion. This article compares and contrasts cohabitation with marriage (and other marital statuses) on two dimensions of social engagement:social networks and prosocial behaviour.
Christoph M. Schimmele, Zheng Wu
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Experiencing augmented reality for social engagement in a network environment

open access: yes, 2011
This paper describes how Augmented Reality (AR) can be utilized to create social engagement in a network environment. The project called Virtual Merdeka incorporated AR as a social networking platform via Facebook to promote Malaysian Independence Day ...
Rafi, Ahmad   +5 more
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

“Serving the Lord”: Christianity, Work, and Social Engagement in China

open access: yesReligions, 2019
This study examines how Chinese evangelical Protestant employees view work and the workplace, through the lens of their religion, and how they seek to influence the broader society, in a highly restrictive religious domain in China.
Francis K. G. Lim
doaj   +1 more source

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