Results 71 to 80 of about 463,339 (267)

Sulfonylurea prescription patterns in elderly patients with type 2 diabetes mellitus: A comprehensive analysis of real‐world data from pharmacies in Japan

Journal of Diabetes Investigation
Aims/Introduction The study aim was to investigate sulfonylurea prescription patterns in elderly patients (age ≥65 years) with type 2 diabetes mellitus in Japan. Sulfonylurea use among older adults has been insufficiently examined, despite the associated
Michiko Yamazaki, Tohru Takebe, Masaya Hosokawa, Tomoya Saika, Yutaka Nakao, Shunya Ikeda, Masaya Sakamoto   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A global ‘Common Core’ framework for family medicine faculty development: Getting the right person, doing the right thing, right!

African Journal of Primary Health Care & Family Medicine
Background: Family medicine is a medical speciality with a global reach, with common core principles but significant regional variations in training pathways, certification and recognition and clinical practice.
Esther M. Johnston, Ramakrishna Prasad, Bassim Birkland, Klaus B. von Pressentin, Sophie Watson, Annika Carlson, Shailendra Prasad   +6 more
doaj   +1 more source

Older men learning through religious and political affiliations: case studies from Malta

AS: Andragoška Spoznanja, 2014
This article examines two case studies from Malta that focus on older men learning through informal channels. The first case study investigated the role of a community-based organisation - namely, a religious confraternity dedicated to 'Our Lady of ...
Marvin Formosa, Roberta Chetcuti Galea, Rosette Farrugia Bonello   +2 more
doaj   +1 more source

Cohabitation and social engagement

Canadian Studies in Population, 2012
In Canada, nonmarital cohabitation has become a normative life experience, but there are uncertainties regarding its contribution to social cohesion. This article compares and contrasts cohabitation with marriage (and other marital statuses) on two dimensions of social engagement:social networks and prosocial behaviour.
Christoph M. Schimmele, Zheng Wu
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Adult ADHD: A Narrative Review of Symptoms, Assessment, and Intervention Strategies

Buletin Psikologi
Attention-Deficit/Hyperactivity Disorder (ADHD) is recognized as a neurodevelopmental condition that persists across the lifespan; however, research focusing on adults with ADHD has received comparatively less attention than studies in children.
Farra Anisa Rahmania, Dwi Fadhila
doaj   +1 more source