Results 111 to 120 of about 2,195,820 (278)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
AI-Driven Vishing Attacks: A Practical Approach
Engineering ProceedingsToday, there are many security problems at the technological level, especially in telecommunications. Cybercriminals invade and steal data from any system using vector attacks such as phishing through scam mail, fake websites and phone calls. This latter
Fabricio Toapanta +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Microservices and Machine Learning Algorithms for Adaptive Green Buildings [PDF]
, 2019 In recent years, the use of services for Open Systems development has consolidated and strengthened. Advances in the Service Science and Engineering (SSE) community, promoted by the reinforcement of Web Services and Semantic Web technologies and the ...
Alonso Montesinos, Joaquín Blas +6 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Social Engineering on Mangrove Preservation Based on Fishermen's Local Wisdom [PDF]
, 2017 Kampung Laut Segara Anakan is a mangrove forest area which has a wealth of biodiversity and ecotourism. For a couple of years, mangrove forest has suffered the destruction caused by the lack of wise (immanent) and not transcendent.
Suyanto, E. (Edy) +3 more
core
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
An Introduction to the Integrated Community-Engaged Learning and Ethical Reflection Framework (I-CELER) [PDF]
, 2018 Cultivating ethical Science, Technology, Engineering, and Mathematics researchers and practitioners requires movement beyond reducing ethical instruction to the rational exploration of moral quandaries via case studies and into the complexity of the ...
Coleman, Martin A. +6 more
core
A social engineering model for poverty alleviation. [PDF]
Nat Commun, 2020 Chattopadhyay AK, Kumar TK, Rice I.
europepmc +1 more source