Results 71 to 80 of about 13,492,077 (298)

Moments of the Negative. Two Small Nihilist Episodes from the 1940s [PDF]

Phainomena
Evoking Leo Strauss’s 1941 text “German Nihilism” and his forceful claim that nihilism is above all “the rejection of the principles of civilization as such,” my intention is to thematize the possible forms of coexistence that survive and develop despite
Petar Bojanić
doaj   +1 more source

Opinion of society as a basis of international relations — analysis of data of public-opinion polls «how citizens of China cognize the world?» [PDF]

Экономика региона, 2012
International links of China were intensified with the realization of policy of reforms. It becomes relevant to understand, how citizens of China cognize the world.
Pan Daly
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Representations of Social Europe

, 2014
Two main political and economic paradigms have framed the Social Europe so far. The first one has consisted in the (German) "ordoliberalism", which has played a key role in structuring the foundations of the European Community as well as those of the Monetary Union.
Lechevalier, Arnaud, Laruffa, Fransesco, Salles, Maryse, Colletis, Gabriel   +3 more
openaire   +3 more sources

Health and social inequality in Europe [PDF]

BMJ, 1994
In most European countries health has been shown to be linked to social circumstances--gradients in health status have persisted for decades, despite major changes in the principal causes of death. In central and eastern Europe life expectancy has stagnated since the mid-60s, whereas in the West it has increased; but even in the West it is related to ...
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Annex 6 : What future for Social Europe ?. [PDF]

‘Social Europe’ has various meanings. It may refer to the current intervention of European authorities in the fields of social protection and employment legislation, as a complement or sometimes as a substitute to national institutions interventions. The
Sterdyniak, Henri, Mathieu, Catherine, Seguin, Thomas   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source