Results 41 to 50 of about 504,419 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

CONSEQUENCES OF GLOBALIZATION: MENTAL STRESS IN MANAGEMENT [PDF]

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2017
Due to mass consolidation and permanent restructuring of process flows in a global context, people are increasingly falling into routine and predetermined life patterns.
Frantisek DROZEN, Rudolf BRABECK
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On the road to intersectional mainstreaming? EU (gender) equality policy between intersectionality and anti-gender backlash

open access: yesGlobal Social Challenges Journal
In the wake of the 2024 European Parliament elections and the subsequent recast of the European Commission, this article looks at the opportunities that have not yet been fully exploited to further advance gender equality in the European Union. Crucially,
Katrin Lange, Julia Lux
doaj   +1 more source

Collaborating as peers or targeted by science diplomacy? The participation of Latin American researchers in the European Framework Programme for Research and Innovation

open access: yesTapuya, 2022
In this paper, we discuss whether Latin American researchers participate in the European Research and Innovation Framework Programme (FP) by joining European colleagues as peers, or by being targeted as part of a science diplomacy initiative.
Consuelo Uribe-Mallarino
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Social Europe: A Manifesto

open access: yes, 2020
The European Union is excellently equipped to pursue the most urgent issues facing the advanced world: combating environmental damage and climate change, coping with the massive aftermath of the coronavirus crisis, reforming globalisation, regulating ...
Crouch, C.
core  

Eco-social market economy as an European innovation

open access: yesAgricultural Economics (AGRICECON), 2003
The paper presents fundamental ideas of European social market economy that are to be applied to formulate the "European Model of Agriculture". In connection with the needs of further development of the Common Agricultural Policy, food strategy and ...
J. Riegler
doaj   +1 more source

Patients, payers and developers of Orphan Medicinal Products: lessons learned from 10 years’ multi-stakeholder dialogue on improving access in Europe via MoCA

open access: yesOrphanet Journal of Rare Diseases, 2023
Background The Mechanism of Coordinated Access to Orphan Medicinal Products (MoCA) was established in 2013 with the intention of developing a coordinated mechanism between volunteering EU stakeholders and developers of Orphan Medicinal Products (OMPs) to
Maria Cavaller-Bellaubi   +10 more
doaj   +1 more source

The Determinants of Social Connectedness in Europe [PDF]

open access: yes, 2020
Abstract We use de-identified and aggregated data from Facebook to study the structure of social networks across European regions. Social connectedness declines strongly in geographic distance and at country borders. Historical borders and unions—such as the Austro-Hungarian Empire, Czechoslovakia, and East/West Germany—shape present-day social ...
Michael C. Bailey   +5 more
openaire   +1 more source

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