Results 51 to 60 of about 504,419 (304)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Outpatient services and primary care: scoping review, substudies and international comparisons
Health Services and Delivery Research, 2016 Aim: This study updates a previous scoping review published by the National Institute for Health Research (NIHR) in 2006 (Roland M, McDonald R, Sibbald B.
Eleanor Winpenny +7 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
European solidarity : silver linings through dark clouds
, 2022 Published online: 6th June 2022It is striking how vocal and proactive the European Commission and other European Union institutions (such as the European Central Bank) have become on issues of European solidarity in recent years.
RUSSO, Luís +2 more
core
, 2022 Abstract This chapter examines the efforts undertaken by the then rising European Left—especially European socialist parties—to finally outline a concrete programme for a ‘social Europe’ in the run-up to the adoption of the European Community’s (EC’s) first Social Action Programme (1972–4).
openaire +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Migrants shaping Europe, past and present
, 2022 This comparative volume examines the sustained contribution of migrants to Europe’s literatures, social cultures, and arts over centuries. Europe has never been a continent bounded by the seas that surround it.
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Europe to Keep Leading COVID-19 Pandemic and Crisis Recovery
, 2020 Science Europe encourages EU Member States and Associated Countries to keep leading European and global projects to tackle the medical, social, and economic challenges brought on by COVID-19.
Science Europe
core +1 more source