Results 41 to 50 of about 2,460,681 (299)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Parasocial Romance: A Social Exchange Perspective

open access: yesInterpersona: An International Journal on Personal Relationships, 2013
Parasocial relationships are one-sided relationships that people hold with media figures. Although it has been previously demonstrated that people often feel strong friendships with people that they have never met, parasocial romantic attachments have ...
Aimee Adam, Brittany Sizemore
doaj   +1 more source

Uang Panggilan: Media Pertukaran Sosial dan Tolong Menolong dalam Masyarakat Gadih Angik

open access: yesIndonesian Journal of Religion and Society, 2021
This study raises the theme of Uang panggilan in the Gadih Angik Community Tradition. Call money is a form of tradition in the form of giving a kind of money to the host who is holding a baralek event.
Zainal Abidin, Hulwati Hulwati
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Don’t Ask, Don’t Tell: A Study on Whistleblowing Behavior in Indonesia State-owned Enterprises Original file 752-1679-1-SM.pdf 2023-11-23

open access: yesThe Indonesian Journal of Accounting Research
Employees or subordinates can potentially engage in unethical behavior with their superiors both for themselves and their superiors, even though it can be detrimental to the organization as a whole.
Haikal Firmansah, Dian Kartika Rahajeng
doaj   +1 more source

Should Employers Invest in Employability? Examining Employability as a Mediator in the HRM – Commitment Relationship

open access: yesFrontiers in Psychology, 2019
This study investigates the relationship between perceived investments in Human Resource (HR) practices and workplace commitment, from the perspective of social exchange theory.
Jos Akkermans   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Exploring individual, social and organisational effects on Web 2.0-based workplace learning: a research agenda for a systematic approach

open access: yesResearch in Learning Technology, 2013
Web 2.0-based workplace learning is defined in this article as informal learning that takes place in the workplace through connections and collaborations mediated by Web 2.0 technology.
Fang Zhao, Linzi Kemp
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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