Results 51 to 60 of about 13,495,052 (294)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Essays on actor perspectives in exchange networks and social dilemmas, 1999

open access: yes, 2007
Essays on actor models in exchange networks and social dilemmas. Measuring utility by means of the tradeoff method / relation between actors' utility and their behavior in prisoners' dilemma games / bargaining in exchange networks / micro-models of ...
M. van Assen, RU Groningen, Sociologie/ICS (primary investigator)
core   +1 more source

Don’t Ask, Don’t Tell: A Study on Whistleblowing Behavior in Indonesia State-owned Enterprises Original file 752-1679-1-SM.pdf 2023-11-23

open access: yesThe Indonesian Journal of Accounting Research
Employees or subordinates can potentially engage in unethical behavior with their superiors both for themselves and their superiors, even though it can be detrimental to the organization as a whole.
Haikal Firmansah, Dian Kartika Rahajeng
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Exploring individual, social and organisational effects on Web 2.0-based workplace learning: a research agenda for a systematic approach

open access: yesResearch in Learning Technology, 2013
Web 2.0-based workplace learning is defined in this article as informal learning that takes place in the workplace through connections and collaborations mediated by Web 2.0 technology.
Fang Zhao, Linzi Kemp
doaj   +1 more source

Social computing in currency exchange

open access: yesKnowledge and Information Systems, 2019
[EN]Human communication has evolved over the last decades thanks to rapid technological advances. It has provided us with new ways of communicating with one another and made many aspects of social interaction easier. Social computing is an important area in computer science concerned with the use of computational systems for social purposes. This paper
Chamoso Santos, Pablo   +4 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Intermarriages: Factors, Characteristics and their Impact on Family and Society (Foreign Research Review)

open access: yesСоциологический журнал
Intermarriage is one of the striking examples of extreme diversity as a key characteristic of the modern world. The most common and the most actively studied form of intermarriage are interracial, interethnic and interfaith marriages, as evidenced by the
Vera M. Peshkova
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Big Ideas Exchange -- Coming May 16, 2019 [video]

open access: yes, 2019
The Big Ideas Exchange (BIX) is our opportunity to share the game-changing research of NPS faculty and students that directly addresses grand challenges in American national security. The next BIX, coming May 16, 2019, at 3:00 p.m.

core   +2 more sources

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