Results 51 to 60 of about 340,184 (306)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Don’t Ask, Don’t Tell: A Study on Whistleblowing Behavior in Indonesia State-owned Enterprises Original file 752-1679-1-SM.pdf 2023-11-23

open access: yesThe Indonesian Journal of Accounting Research
Employees or subordinates can potentially engage in unethical behavior with their superiors both for themselves and their superiors, even though it can be detrimental to the organization as a whole.
Haikal Firmansah, Dian Kartika Rahajeng
doaj   +1 more source

Exploring individual, social and organisational effects on Web 2.0-based workplace learning: a research agenda for a systematic approach

open access: yesResearch in Learning Technology, 2013
Web 2.0-based workplace learning is defined in this article as informal learning that takes place in the workplace through connections and collaborations mediated by Web 2.0 technology.
Fang Zhao, Linzi Kemp
doaj   +1 more source

Social computing in currency exchange

open access: yesKnowledge and Information Systems, 2019
[EN]Human communication has evolved over the last decades thanks to rapid technological advances. It has provided us with new ways of communicating with one another and made many aspects of social interaction easier. Social computing is an important area in computer science concerned with the use of computational systems for social purposes. This paper
Chamoso Santos, Pablo   +4 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Intermarriages: Factors, Characteristics and their Impact on Family and Society (Foreign Research Review)

open access: yesСоциологический журнал
Intermarriage is one of the striking examples of extreme diversity as a key characteristic of the modern world. The most common and the most actively studied form of intermarriage are interracial, interethnic and interfaith marriages, as evidenced by the
Vera M. Peshkova
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Unlocking public sector potential: the interplay of leadership traits, trust, and employee voice

open access: yesCogent Business & Management
This research analyzes how leadership traits affect performance in the public sector with regard to employee voice and trust as mediators, using the Leader-Member Exchange (LMX) theory as a guide.
Issah Iddrisu
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

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