Results 51 to 60 of about 1,520,531 (279)

Marrying Up by Marrying Down: Status Exchange between Social Origin and Education in the United States

open access: yesSociological Science, 2016
Intermarriage plays a key role in stratification systems. Spousal resemblance reinforces social boundaries within and across generations, and the rules of intermarriage govern the ways that social mobility may occur.
Christine R. Schwartz, Zhen Zeng, Yu Xie
doaj   +1 more source

The Theory of Relational Cohesion: Review of a Research Program [PDF]

open access: yes, 2002
In this paper we analyze and review the theory of relational cohesion and attendant program of research. Since the early 1990s, the theory has evolved to answer a number of basic questions regarding cohesion and commitment in social exchange relations ...
Lawler, Edward J   +2 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Psycho-social effects of a brain-training program among healthy older adults [PDF]

open access: yes, 2008
Grounded in cognitive neuroscience and social exchange theory, this research evaluated the relationship between changes in cognitive functioning and two psycho-social dimensions of life among healthy adults over the age of 70 (N=12).
Bailey, William C.   +2 more
core   +2 more sources

Defections From The Inner Circle: Social Exchange, Reciprocity, And The Diffusion Of Board Independence In Us Corporations [PDF]

open access: yes, 1997
This study seeks to reconcile traditional sociological views of the corporate board as an instrument of elite cohesion with recent evidence of greater board activism and control over top management.
Westphal, J. D., Zajac, E. J.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Reading Speculative Futures in a Post-Truth World [PDF]

open access: yes, 2017
Faced with the threat of a “post-truth” world and a widening chasm of exchange between climate change deniers and environmentalists, I argue that future-orientated literary and media speculative fictions—which I term “speculative futures”—offer a means ...
Jekanowski, Rachel Webb
core   +1 more source

Perceived organizational support and organizational identification : joint moderating effects of employee exchange ideology and employee investment [PDF]

open access: yes, 2014
Organizational identification (OID) can be developed out of social exchange practices within an organizational setting. Drawing on social exchange theory, we propose that the effect of perceived organizational support (POS) on OID is stronger for ...
Cornelissen J.P.   +7 more
core   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

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