Results 51 to 60 of about 1,290,740 (256)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The difference that tenure makes [PDF]

, 1991
This paper argues that housing tenures cannot be reduced to either production relations or consumption relations. Instead, they need to be understood as modes of housing distribution, and as having complex and dynamic relations with social classes ...
Andrew Knowles, Bagguley P., Bassett K., Batstone E., Beynon H., Bottomore T., Bradley H., Braverman M., Buck N., Byrne D., Byrne D., Carpenter M., Coates D., Cockbum C., Cooke P., Cousins C., Dahrendorf R., Daunton M. J., de Vroey M., Department of the Environment, Dickens P., Donnison D., Dunleavy P., Ehrenreich B., Forrest R., Forrest R., Gamarnikow E., Goldthorpe J. H., Gordon D. M., Gorz A., Gray F., Hamnett C., Harloe M., Harloe M., Harloe M., Henderson J., Johnson T., Kam V., Kemeny J., Knowles A., Littler C. R., Malpass P., Malpass P., Marshall G., Meegan R., Morris J., Murie A, Murie A., Murie A., Nichols T., Pahl R., Parry N. C. A., Parry N. C. A., Peter Somerville, Pringle R., Rae D. W., Robinson R., Saunders P., Saunders P., Saunders P., Somerville P., Somerville P., Somerville P., Somerville P., Stedman Jones G., Thrift N., Urry J., Willmott P., Wright E. O.   +68 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Servant Leadership for Sustainability: A Serial Mediation Model of Empowerment, Creativity, and Pro-Environmental Behavior

Administrative Sciences
This study examines the impact of Environmentally Specific Servant Leadership (ESSL) on employees’ pro-environmental behavior (PEB) by proposing a serial mediation model that incorporates green psychological empowerment and green creativity as central ...
Farida Saleem, Sofia Mateou
doaj   +1 more source

Urban geography: urban growth machine [PDF]

, 2009
Urban growth machine is an influential thesis of urban politics that suggests the objective of growth unites otherwise pluralistic interests in relation to a city.
Rodgers, Scott
core  

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

A generic model of dyadic social relationships

, 2015
We introduce a model of dyadic social interactions and establish its correspondence with relational models theory (RMT), a theory of human social relationships. RMT posits four elementary models of relationships governing human interactions, singly or in
Favre, Maroussia, Sornette, Didier
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Motivation Factors On Knowledge Sharing Among Public Sector Organizations In Malaysia [PDF]

, 2012
Tujuan utama kajian dijalankan adalah bagi mengenalpasti faktor-faktor yang mempengaruhi perkongsian pengetahuan di kalangan organisasi sektor kerajaan di Malaysia.
Baharul Azhar , Nurin Hanani
core   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source