Results 81 to 90 of about 1,821,326 (334)

Barreiras à higiene das mãos num serviço de urgência segundo os profissionais de saúde

RIIS: Revista de Investigação & Inovação em Saúde
Enquadramento: a higienização das mãos é considerada a medida mais simples e efetiva na redução de infeções associadas aos cuidados de saúde. Objetivos: analisar a perceção dos profissionais de saúde de um serviço de urgência acerca das barreiras às ...
Filomena Silva, Pedro Costa, Fátima Braga, Silvana Martins   +3 more
doaj   +1 more source

SOCIAL EXCLUSION AND VULNERABLE POPULATIONS [PDF]

Annals of the University of Petrosani: Economics, 2013
In the last half of the century, significant technological, economic, demographic, political, and ideological changes took place; advanced democracies went to a process of deep economic restructurings.
ROXANA PLEŞA
doaj  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Exclusionary employment in Britain’s broken labour market [PDF]

, 2016
There is growing evidence of the problematic nature of the UK’s ‘flexible labour market’ with rising levels of in-work poverty and insecurity. Yet successive Governments have stressed that paid work is the route to inclusion, focussing attention on the ...
Aldridge H, Bailey N, Bailey N, Barnes M, Berghman J, Blond P, Burchardt T, Byrne D, Coote A, Department for Business, Innovation and Skills (BIS), Department for Work and Pensions (DWP), Department for Work and Pensions (DWP), Department for Work and Pensions (DWP), Department for Work and Pensions (DWP), Eurofound, Eurofound, Gallie D, Gordon D, House of Commons Work and Pensions Committee, Kenway P, Levitas R, Levitas R, Millward N, Office for National Statistics (ONS), Organisation for Economic Cooperation and Development (OECD), Organisation for Economic Cooperation and Development (OECD), Pantazis C, Platt L, Scottish Government, Skinner C, Standing G, Thompson S, Tomlinson M   +32 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Development of a social inclusion index to capture subjective and objective life domains (Phase II): psychometric development study

Health Technology Assessment, 2012
Objectives: To produce a robust measure of social inclusion [Social and Community Opportunities Profile (SCOPE)] that is multidimensional and captures multiple life domains; incorporates objective and subjective indicators of inclusion; has sound ...
P Huxley, S Evans, S Madge, M Webber, T Burchardt, D McDaid, M Knapp   +6 more
doaj   +1 more source

Child social exclusion and health outcomes: a study of small areas across Australia [PDF]

Australian children living in areas with a relatively high risk of social exclusion also experience relatively poor health outcomes, argues this bulletin.

core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source