Results 81 to 90 of about 1,835,724 (288)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The patterns and causes of social exclusion in Luxembourg [PDF]
The paper investigates the forms and determinants of social exclusion in Luxembourg and addresses both conceptual and empirical issues. We therefore examine the following issues: what definition of social exclusion is more appropriate for Luxembourg, if ...
Raileanu Szeles, Monica
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Barreiras à higiene das mãos num serviço de urgência segundo os profissionais de saúde
RIIS: Revista de Investigação & Inovação em SaúdeEnquadramento: a higienização das mãos é considerada a medida mais simples e efetiva na redução de infeções associadas aos cuidados de saúde. Objetivos: analisar a perceção dos profissionais de saúde de um serviço de urgência acerca das barreiras às ...
Filomena Silva +3 more
doaj +1 more source
Exploring Social Exclusion in the European Union, a Quantitative Approach [PDF]
, 2012 Social exclusion is a widely debated issue. Its definitions and perceptions vary. Within the paper we identify the underlying factors of social exclusion within the EUfor years 2005-2009 through the use of factor analysis.
Gavuliak, Roman
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
SOCIAL EXCLUSION AND VULNERABLE POPULATIONS [PDF]
Annals of the University of Petrosani: Economics, 2013 In the last half of the century, significant technological, economic, demographic, political, and ideological changes took place; advanced democracies went to a process of deep economic restructurings.
ROXANA PLEŞA
doaj
Exclusão social e responsabilidade social empresarial Exclusión social y responsabilidad social empresarial Social exclusion and social responsibility in business
Psicologia em Estudo, 2006 Responsabilidade social empresarial é um dos novos fenômenos de mercado precipitados pela globalização da economia. Ao longo dos ciclos históricos, tivemos a empresa orientada sucessivamente para o produto, para o mercado e para o cliente.
Marley Rosana Melo de Araújo
doaj +1 more source
On the side of the angels: community involvement in the governance of neighbourhood renewal. [PDF]
, 2005 This article draws upon the authors’ experiences of community-led regeneration developed while members of the National Evaluation Team for the NDC Programme.
Atkinson R. +22 more
core +2 more sources