Results 81 to 90 of about 12,563,706 (287)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Social exclusion mobility in Spain, 1994-2000 [PDF]
Social exclusion can be defined as a process leading to a state of multiple functioning deprivations. Cross-sectional headcount ratios of social exclusion may overstate the extent of the problem if most individuals do not remain in the same state in ...
Ambra Poggi
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Social Exclusion: the Concept and Application to Developing Countries [PDF]
The feasibility of operationalisation of the 'social exclusion' concept in developing countries is investigated in this paper. The origins of the approach in relation to the welfare state and unemployment status and its spread in Western Europe and ...
Ruhi Saith
core
Child social exclusion and health outcomes: a study of small areas across Australia [PDF]
, 2014 Australian children living in areas with a relatively high risk of social exclusion also experience relatively poor health outcomes, argues this bulletin.
core
Barreiras à higiene das mãos num serviço de urgência segundo os profissionais de saúde
RIIS: Revista de Investigação & Inovação em SaúdeEnquadramento: a higienização das mãos é considerada a medida mais simples e efetiva na redução de infeções associadas aos cuidados de saúde. Objetivos: analisar a perceção dos profissionais de saúde de um serviço de urgência acerca das barreiras às ...
Filomena Silva +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Schools, Education and Social Exclusion [PDF]
A review of research evidence suggests that low levels of educational attainment are crucial in generating and sustaining social exclusion. Test scores at school are the most effective predictor of many adult outcomes.
Jo Sparkes
core
SOCIAL EXCLUSION AND VULNERABLE POPULATIONS [PDF]
Annals of the University of Petrosani: Economics, 2013 In the last half of the century, significant technological, economic, demographic, political, and ideological changes took place; advanced democracies went to a process of deep economic restructurings.
ROXANA PLEŞA
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source