Results 111 to 120 of about 11,754,435 (295)

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

Do malnutrition, sarcopenia and frailty overlap in nursing-home residents?

, 2020
Objectives: To study the prevalence and overlap between malnutrition, sarcopenia and frailty in a selected group of nursing home (NH) residents. Design Cross-sectional descriptive study. Setting: Nursing homes (NH). Participants: 92 residents taking part
Faxen-Irving, G.,, Boström, A-M, Franzen, E., Luiking, Y., Luiking, Y.,, Grönstedt, H.,, Vikström, S., Wimo, A., Boström, A-M,, Grönstedt, H., Seiger, Å.,, Faxen-Irving, G., Seiger, Å., Vikström, S.,, Cederholm, Tommy,, Cederholm, Tommy, Franzen, E.,, Wimo, A.,   +17 more
core   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Elderly frailty in a social center

Revista de Enfermagem da UFPI, 2020
DOI: https://doi.org/10.26694/reufpi.v9i0.9559 Objetivo: avaliar a fragilidade clínico-funcional de idosos participantes de um centro de convivência. Metodologia: estudo com delineamento transversal, com 216 idosos de um centro de convivência em Teresina – PI.
openaire   +1 more source

A shared frailty semi-parametric markov renewal model for travel and activity time-use pattern analysis [PDF]

This study investigates the influence of observed explanatory factors and unobserved random effect (heterogeneity) on episode durations of travel-activity chain.
Charles Raux, Iragaël Joly, Tai-Yu Ma
core  

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

COVID-19 and frailty-Social aspects of frailty-

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2023
openaire   +3 more sources

Social frailty as a predictor of all-cause mortality and functional disability: a systematic review and meta-analysis

Scientific Reports
The association between social frailty and adverse health outcomes, especially mortality and functional disability, which are essential health outcomes, has not been systematically summarized or meta-analyzed.
Takaharu Goto, Takahiro Kishimoto, Shinji Fujiwara, Yasuhiko Shirayama, Tetsuo Ichikawa   +4 more
doaj   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Blood pressure variability and frailty in end-stage kidney disease [PDF]

Tom Mercer - ORCID: 0000-0002-5078-4769 https://orcid.org/0000-0002-5078-4769Marietta van der Linden - ORCID: 0000-0003-2256-6673 https://orcid.org/0000-0003-2256-6673Background High blood pressure variability (BPV) is a predictor of cardiovascular ...
Mercer, Tom, van der Linden, Marietta, Zanotto, Tobia, Koufaki, Pelagia   +3 more
core   +1 more source