Results 81 to 90 of about 11,754,435 (295)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Impact of Japan’s Revised Infectious Disease Control Law on Older Adults’ Social Life during the COVID-19 Pandemic [PDF]

Annals of Geriatric Medicine and Research
Background In May 2023, Japan reclassified coronavirus disease 2019 (COVID-19) under the Infectious Disease Control Law. However, there have been insufficient examinations on how the change in classification has impacted citizens’ lives.
Kohji Iwai, Yuta Kubo, Takeshi Yamazaki, Takahiro Hayashi   +3 more
doaj   +1 more source

Goodness-of-fit tests for the frailty distribution in proportional hazards models with shared frailty. [PDF]

Frailty models account for the clustering present in grouped event time data. A proportional hazards model with shared frailties expresses the hazard for each subject. Often a one-parameter gamma distribution is assumed for the frailties. The choice of a
Claeskens, Gerda, Janssen, Paul, Geerdens, Candida   +2 more
core  

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

Social frailty among older people [PDF]

, 2020
Indexación ScopusSocial frailty is a seldom explored concept in older people. There is dissent if it should be considered a multidimensional syndrome or it should be limited to the physical sphere.
Zúñiga Hernández, Carol, Hernández C.Z.   +1 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

A longitudinal study on multiple frailty and its associations with depression and social participation in older adults

Scientific Reports
To explore the changes in the physical, cognitive, and social frailty over a two-year follow-up and to identify the predictors associated with multiple frailty.
JuHee Lee, Jungah Park, Miji Kim, Sumi Lee, Chang Won Won   +4 more
doaj   +1 more source

The Dynamic Associations of Social and Intellectual Activity With Frailty Trajectory in Middle-Aged and Older Adults in China: Nationwide Longitudinal Study

JMIR Aging
BackgroundResearch on the effects of social and intellectual activities on frailty remains limited, particularly longitudinal studies examining how these activities influence the dynamic progression of frailty over time.
Fei Xu, Xinlei Miao, Shuang Liu, Yangxuan He, Meng Li, Jiayi Deng, Yilin Zhu, Jingshan Jiang, Song Leng   +8 more
doaj   +1 more source

Investigating the role of frailty in the expression of dementia

, 2020
Background: Frailty is related to neuropathological features of Alzheimer’s disease (AD) as well as cognitive decline and dementia. Objectives: 1) determine whether frailty moderates the relationship between neuropathology and dementia status in ...
Wallace, Lindsay M K
core  

Efficient Sunlight Degradation of Wide‐Spectrum Antibiotics Through Enhanced Charge Separation in SnTCPP NPs‐Nb2C Schottky Heterojunction: Ultrafast Carrier Dynamic Study

Advanced Materials Interfaces, EarlyView.
Due to enhanced charge transfer and carrier mobility on the surface, the SnTCPP NPs‐Nb2C Schottky heterojunctions demonstrate exceptional sunlight‐driven catalytic activity toward tetracycline antibiotics and ofloxacin degradation, achieving a removal efficiency of up to 99.9% within 60 min of irradiation, both in model wastewater and natural water ...
Juanxuan Guo, Sheng Liao, Ranye Liao, Xinyan Ke, Ming‐De Li, Li Dang   +5 more
wiley   +1 more source