Results 131 to 140 of about 5,668,569 (360)

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

For the likes of us? Retelling the classed production of a British university campus [PDF]

open access: yes, 2015
This paper contributes to recent critical geographical writing on university campuses by setting their physical production and reproduction centre stage and taking an historical perspective. Focusing on a single case study campus in the UK we revisit the
Rogaly, Ben, Taylor, Becky
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Comparative media history, an introduction: 1789 to the present [PDF]

open access: yes, 2005
This book aims to give a greater insight into the modern history of the media by considering influences on developments within a framework that uses a comparative approach to weigh up continuity versu change.
Chapman, Jane
core  

A tale of two towns: Water provision and management in the towns of Beaufort West and Vanrhynsdorp, c. 1900–1970

open access: yesContree
The Karoo region of South Africa receives some of the lowest annual precipitation in South Africa. The towns of Beaufort West and Vanrhynsdorp share a history of unreliable water supplies, coupled with extreme poverty that left a large section of the ...
Wessel P. Visser, Daniel R. Rademan
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

One market or many? London and the grain trade of England [PDF]

open access: yes, 2000
Paper given at a conference organised by the Centre for Metropolitan History and supported by the Economic and Social Research Council, 7 July ...
Galloway, James A.
core  

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