Results 141 to 150 of about 1,533,792 (313)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modalities of Social Authority: Suggesting an Interface for Religious and Social History

, 2003
The dominant approaches in Canadian social history have focused, for the most part, upon categories of region, class formation, and women’s experience (more recently informed by theories of gender).
Gauvreau, Michael, Christie, Nancy
core  

Elements of Reflection for the Near Future of Social Education [PDF]

, 2018
En aquest treball es fa un repàs dels moments més rellevants de la història recent de l’educació social per comprendre on es troba avui en dia. En segon lloc, es plantegen algunes idees bàsiques sobre l’estreta relació que s’estableix entre l’educació ...
Vilar Martín, Jesús
core  

Life Expectancy at Birth: the Numbers Behind the Means

, 2017
Datasets spanning long periods of time, are crucial to our understanding of a range of phenomena, both within as outside social and economic history. For various processes, from social inequality to climate change, only change gradually, requiring long ...
Richard Lindert Zijdeman, Zijdeman, Richard L.   +1 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Channels of History - A Social History Exhibition of the Women, Land and History of the Channel Country

, 2004
Research Background: Channels of History is part of a recent international trend to explore intersections of documentary film and digital technologies to create media rich exhibitions as part of the 'new museology' (Witcomb 2003). It is 'relational art' (
FitzSimons, Trish
core  

Resisting colonial and feudal oppression: the Bhil revolts in British Raj Rajasthan and their impact on India's freedom movement

Discover Global Society
This research paper examines the significant yet often overlooked revolts of the Bhil tribe in Rajasthan during the British Raj, focusing on their resistance against colonial and feudal oppression from the early 19th to the early twentieth century.
Vishal Singh Bhadauriya, Anuradha Singh, Rituparna Bhattacharyya   +2 more
doaj   +1 more source

Health Insurance Programs, Extended Social History Taking, and Resources to Overcome Health Care Barriers: Introduction for Medical Students. [PDF]

MedEdPORTAL, 2021
Haury E.
europepmc   +1 more source