Results 131 to 140 of about 17,410,214 (348)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Jurnal Sejarah Citra LekhaThis study aims to reaffirm the role of K.H. Mas Mansur in the context of Indonesia's struggle for independence from colonial rule. The research employs historical research procedures, including heuristics (source gathering), verification (criticism of ...
Miftahuddin Miftahuddin +2 more
doaj +1 more source
'Closing the Gaps': From postcolonialism to Kaupapa Māori and beyond. [PDF]
, 2011 The article discusses New Zealand history, particularly examining Māori theories and interpretations of history. It considers postcolonial theory and Kaupapa Māori theory.
Mahuika, Nepia
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Journal of Responsible TechnologyDespite regulatory efforts, there is a significant governance gap in managing emotion recognition AI technologies and those that emulate empathy. This paper asks: should international soft law mechanisms, such as ethical standards, complement hard law in
Andrew McStay, Vian Bakir
doaj +1 more source
Conceptual History, Cultural History, Social History
ВИВЛIОθИКА: E-Journal of Eighteenth-Century Russian Studies, 2014 V. M. Zhivov’s introduction to Studies in Historical Semantics of the Russian Language in the Early Modern Period (2009), translated here for the first time, offers a critical survey of the historiography on Begriffsgeschichte, the German school of conceptual history associated with the work of Reinhart Koselleck, as well as of its application to the ...
openaire +4 more sources
Comparative media history, an introduction: 1789 to the present [PDF]
, 2005 This book aims to give a greater insight into the modern history of the media by considering influences on developments within a framework that uses a comparative approach to weigh up continuity versu change.
Chapman, Jane
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Trade, urban hinterlands and market integration, 1300-1600: a summing up [PDF]
, 2000 Paper given at a conference organised by the Centre for Metropolitan History and supported by the Economic and Social Research Council, 7 July ...
Dyer, Christopher
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