Results 91 to 100 of about 3,093,745 (311)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Participación social para el desarrollo local. El caso del municipio de San Luis, Santiago de Cuba

open access: yesInterconectando Saberes, 2019
La investigación Participación social para el desarrollo local. El caso del municipio de San Luis, Santiago de Cuba analiza los factores socioculturales que inciden en la participación social para el desarrollo local de un municipio. Los resultados en el
Farah Maria Muguercia Montes de Oca   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Solidarity economy and environment: alliance between women for a decent environment among localities of Coacoatzintla, Ver.

open access: yesInterconectando Saberes, 2019
The socioeconomic reality of three rural peasant localities in the municipality of Coacoatzintla has provoked the migration of male heads of family with the need to obtain employment in other spaces. The consequence of this phenomenon, among many others,
Claudia Lorena Arellano Olivo
doaj   +1 more source

Beyond ethics to morality: Choices and relationships in bicultural research settings [PDF]

open access: yes, 2013
Knowledge of ourselves as cultural beings, of the values and beliefs of those with whom we work, and of the history of relations among those in our work settings are essential for community and applied social psychologists.
Furness, Jane Amanda   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Economías de aglomeración en servicios hoteleros: los casos de Acapulco, Guerrero y Boca del Río Veracruz en México

open access: yesInterconectando Saberes, 2018
Se presenta una interpretación y análisis comparativo de las aglomeraciones hoteleras en Acapulco y Boca del Río, abarcando un estudio del desarrollo económico – turístico.
Melissa Andrea Bracamonte Jaraba   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Information technologies and gambling: a Durkheimian perspective [PDF]

open access: yes, 2014
Gambling has a long history as a social practice, through which bonds can be created and maintained, and as a part of creative and reenacted social habits and celebrations.
Mundy-McPherson, S
core  

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