Results 111 to 120 of about 3,114,156 (310)
Self-Help and the London Mechanics' Institution - Birkbeck after (George) Birkbeck [PDF]
, 2009 The London Mechanics’ Institute is notable not only for its place in the history of the Mechanics’ Institute movement, but also for the conflicts which surrounded its formation in 1823.
Clarke, Richard
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 2012 Don Dunstan Oral History Project interview transcripts. No conditions are imposed on the reuse of this transcript by the interviewee.Interview with Ian Cox by Bruce Guerin on 5 July 2007.
Cox, Ian [Interviewee] +1 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
La democracia cívica o democracia de las responsabilidades
Interconectando SaberesEl reto inicial es distinguir entre obligaciones y responsabilidades: las primeras son legales y las segundas culturales. Este proyecto introduce el concepto de democracia cívica o democracia de las responsabilidades, enfocándose en analizar hasta dónde
Manuel Ángel Rodríguez Edeza +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Reveses democráticos en América Latina
Interconectando SaberesEste estudio tiene como objetivo analizar el fenómeno de la degradación democrática en América Latina, centrándose en los casos de Venezuela, Nicaragua y El Salvador.
Rodolfo Silva Marques +1 more
doaj +1 more source
PEASANT INITIATIVE FOR SOIL CONSERVATION: CASE STUDIES OF RECENT TECHNICAL AND SOCIAL INNOVATIONS FROM MAISSADE, HAITI [PDF]
Theories of Haitian underdevelopment, and of the causes and solutions to that underdevelopment are many, complex and often competing. At a very basic level though, Haitian development involves the mastery of ever changing conditions and requires ...
White, Thomas A.
core +1 more source