Results 131 to 140 of about 691,597 (256)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Recompiling History: Code Heritage as a Site for Recovering Marginalized Computing Histories

This paper argues that source code constitutes a legitimate primary source for historical inquiry, capable of revealing social, cultural, and personal dimensions of computing history invisible through conventional archival materials.
KAUFFMANN WILL, Titaÿna
core   +1 more source

Pierre Branda (ed.), l'Économie selon Napoléon. Monnaie, banque, crises et commerce sous le Premier Empire.

Tijdschrift voor Sociale en Economische Geschiedenis, 2019
Johan Joor
doaj   +1 more source

Paul Nelles and Rosa Salzberg (eds), Connected Mobilities in the Early Modern World. The Practice and Experience of Movement

Tijdschrift voor Sociale en Economische Geschiedenis, 2023
Alisa Van de Haar
doaj   +1 more source

Stigma as a Social Determinant of Health: A Policy Classification Framework and Call to Action. [PDF]

Milbank Q
Carter-Bawa L.
europepmc   +1 more source

'All the common rules of social life' : the reconstruction of social and political identities by the Dorset Gentry, c.1790-c.1834 [PDF]

This case-history explores the governing purposes of the Dorset gentry from the early 1790's until the mid 1830's. It is not a conventional political and administrative history.
Flame, Michael John
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Rochelle Rowe, Imagining Caribbean Womanhood. Race, Nation and Beauty Competitions, 1929-70

Tijdschrift voor Sociale en Economische Geschiedenis, 2014
Patricia van Leeuwaarde Moonsammy
doaj   +1 more source

Bonobos innovate, plan, and transmit tool use to solve an extractive foraging task. [PDF]

iScience
Zanutto L, Funkhouser JA, Willems EP, Moser A, Sanz C, Clay Z, Koops K.   +6 more
europepmc   +1 more source