Results 121 to 130 of about 3,114,156 (310)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
A cost-benefit approach to labor market reform [PDF]
Labor reforms in Latin America have been scarce compared with the pace of structural reforms aimed at liberalizing product and capital markets. Some analysts contend that without continued liberalization labor market performance will fail to improve ...
Carmen Pages
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Interconectando Saberes, 2017 En el presente artículo se calculará el índice de desempeño ambiental para los estados del sur-sureste de la República Mexicana con el fin de encontrar cuales son los estados de esta región que presentan dificultades en materia ambiental y cuáles son los
Alberto García Leyva
doaj
The evolution of water culture in Malta : an analysis of the changing perceptions towards water throughout the ages [PDF]
, 2008 Since time immemorial, the provision of water in sufficient quantities has been one of the most pressing national problems. This paper will try to analyze the changing public perceptions towards water and its use throughout the last two millennia ...
Attard, George +3 more
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Interconectando Saberes, 2017 En el mundo electrónico en el que vivimos nos encontramos rodeados de fuentes de información: televisión, radio, revistas, periódicos, gacetas, Internet, y de una gran variedad de dispositivos electrónicos.
Erasto Alfonso Marín Lozano
doaj
Professor A.L. Bowley’s theory of the representative method [PDF]
Arthur. L. Bowley (1869-1957) first advocated the use of surveys--the "representative method"--in 1906 and started to conduct surveys of economic and social conditions in 1912.
Aldrich, John
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source