Jerusalem the Holy. A Brief History of Ancient Jerusalem; With an Account of the Modern City and Its Conditions Political, Religious, and Social. Edwin Sherman Wallace [PDF]
n ...
openaire +1 more source
A European perspective on auditory processing disorder-current knowledge and future research focus [PDF]
Current notions of \u201chearing impairment,\u201d as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday ...
Bamiou, Doris-Eva +22 more
core +7 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nonseparable Preferences and Optimal Social Security Systems [PDF]
In this paper, we consider economies in which agents are privately informed about their skills, which are evolving stochastically over time. We require agents' preferences to be weakly separable between the lifetime paths of consumption and labor ...
Borys Grochulski, Narayana Kocherlakota
core +3 more sources
Social pensions Part I : their role in the overall pension system [PDF]
Cash transfers for the elderly with little or no link to previous contribution, or work history are employed in many countries to provide income support for the elderly.
Palacios, Robert, Sluchynsky, Oleksiy
core
Isolated iliac bone tuberculosis : a case report [PDF]
Background: Isolated iliac bone tuberculosis is not easy for diagnosis as it can mimic many other conditions. The presentation of our case of isolated iliac bone tuberculosis with special emphasis to imaging findings is justified, by its rarity and not ...
Ismail, Mostafa +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Benefits of Alaska Native Corporations and the SBA 8(a) Program to Alaska Natives and Alaska [PDF]
Senator Begich’s office asked ISER for assistance assembling information to document the social and economic status of Alaska Natives and the benefits of the 8(a) program.
Ainsworth, Joel +6 more
core
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source

