Results 171 to 180 of about 3,114,156 (310)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Post-traumatic stress disorders among sexual and gender-based violence survivors in war-affected zones in Ethiopia. [PDF]

BMC Public Health
Anbesaw T, Kebede MG, Birhan Z, Kunno K, Melkam M, Kassaw AB, Abera KM.   +6 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

8th International Conference on the History of Occupational and Environmental Health (ICOH History 2026), Recognizing the rich history of occupational and environmental health. [PDF]

J Occup Med Toxicol
europepmc   +1 more source

Social Isolation and Aging health in Schizophrenia spectrum disorders (SIAS): study protocol for a multinational longitudinal study. [PDF]

BMC Psychiatry
Koster M, van der Pluijm M, Baldwin H, Greenburgh A, King D, Arnold C, Lopez-Morinigo JD, Underwood S, Larrauri CA, Racher M, Glahn DC, Harvey PD, Sandin S, Stevens M, Pearlson G, Arango C, Dazzan P, Morgan C, de Haan L, Reichenberg A, Velthorst E.   +20 more
europepmc   +1 more source

LOCAL HISTORY SOCIETIES: CHANGES IN RESEARCHERS AND FUNCTIONAL STRATEGIES IN THE CONDITIONS OF SOCIAL TRANSFORMATIONS IN THE USSR OF THE 20S AND EARLY 30S OF THE 20TH CENTURY

History of Science and Biographical Studies, 2023
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Transition to parenthood: parents' experiences of an extended home visiting programme in socioeconomically disadvantaged areas of Sweden. [PDF]

Int J Equity Health
Lindahl L, Olsson J, Alfredsson E.
europepmc   +1 more source