Results 71 to 80 of about 5,500,695 (406)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Under the Conditions of Non-Agenda Ownership: Social Media Users in the 2019 Ukrainian Presidential Elections Campaign [PDF]

CEUR Workshop Proceedings. Vol 2392: Proceedings of the 1st International Workshop on Control, Optimisation and Analytical Processing of Social Networks, COAPSN-2019, 2019, 2019
Owing to its history and challenging circumstances, social networks community in Ukraine is a very interesting polygon for the study of communications in the constantly changing environment, especially in the political discourse. This unique environment requires three dimensions to ascertain the political position of its participant.
arxiv  

Primary and Secondary Social Media Source Identification [PDF]

arXiv, 2021
Social networks like Facebook and WhatsApp have enabled users to share images with other users around the world. Along with this has come the rapid spread of misinformation. One step towards verifying the authenticity of an image is understanding its origin, including it distribution history through social media.
arxiv  

Simulación numérica de los movimientos en una embarcación de operación offshore

Interconectando Saberes, 2018
El objetivo del presente trabajo es el análisis hidrodinámico de una embarcación de tendido de ductos, de tipo S. El análisis se realizó para condiciones del Golfo de México, considerando un tendido bajo las condiciones de este mar. El trabajo se realizó
Sayra Lourdes Mendoza Jarillo, José Hernández Hernández, Alberto Omar Vázquez Hernández   +2 more
doaj  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Inference on the History of a Randomly Growing Tree [PDF]

arXiv, 2020
The spread of infectious disease in a human community or the proliferation of fake news on social media can be modeled as a randomly growing tree-shaped graph. The history of the random growth process is often unobserved but contains important information such as the source of the infection.
arxiv  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Investigating situated cultural practices through cross-sectoral digital collaborations: policies, processes, insights [PDF]

, 2012
The (Belfast) Good Friday Agreement represents a major milestone in Northern Ireland's recent political history, with complex conditions allowing for formation of a ‘cross-community’ system of government enabling power sharing between parties ...
Bishop C., Bourriaud N., boyd d., Briggs J., Burn A., Castells M., Chandler D., Cooper R., Crooke E., Eisner E. W., Eisner E. W., Hall S., Heddon D., Henderson S., Jo Briggs, Kester G., Kress G., Kwon M., Leeson L., Livingstone S., Lundby K., McCarter G., Murphy A., O'Neill P., Thumim N.   +24 more
core   +1 more source

Quantifying Mental Health from Social Media with Neural User Embeddings [PDF]

arXiv, 2017
Mental illnesses adversely affect a significant proportion of the population worldwide. However, the methods traditionally used for estimating and characterizing the prevalence of mental health conditions are time-consuming and expensive. Consequently, best-available estimates concerning the prevalence of mental health conditions are often years out of
arxiv  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source