Results 101 to 110 of about 177,397 (293)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Changing Identity: The Emergence of Social Groups [PDF]

The original Homo Economicus has progressed from an atomistic and self-interested individual to a socially embedded agent in modern economics. In particular, social interaction models suggest that the individual’s own utility of undertaking an action may
Ulrich Horst, Alan Kirman, Miriam Teschl
core  

Social identity and leadership in the Basque Region: a study of leadership development programmes [PDF]

, 2003
The purpose of the study is to explore how social identity influences the construction of leadership development programmes in the Basque Region. The Basque region is recognised as having a strong social and national identity (Kaufmann and Tödtling, 2000;
Murphy, Anne, Rivera, Olga, Pittaway, Luke   +2 more
core  

Shared identity predicts enhanced health at a mass gathering [PDF]

, 2014
The authors thank the ESRC for funding (RES-062-23-1449).Identifying with a group can impact (positively) upon group members’ health. This can be explained (in part) through the social relations that a shared identity allows.
Tewari, S, Khan, S, Narayanan Srinivasan (302484), Stevenson, C.,, Srinivasan, Narayanan, Clifford Stevenson (9165627), Srinivasan, N.,, Hopkins, N, Hopkins, N.,, Hopkins, Nicholas, Stevenson, C, Khan, SS, Stephen Reicher (302488), Khan, Sammyh,, Khan, S.S., Stevenson, C., Reicher, S.,, Nick Hopkins (302482), Tewari, S.,, Shruti Tewari (302478), Sammyh. S. Khan (16670283), Reicher, Stephen, Tewari, S., Hopkins, N., Reicher, S., Srinivasan, N., Reicher, S, Tewari, Shruti, Srinivasan, N, Stevenson, Clifford, Khan, Sammyh S.   +30 more
core   +1 more source

Understanding Camouflaging as a Response to Autism-Related Stigma: A Social Identity Theory Approach. [PDF]

J Autism Dev Disord, 2022
Perry E, Mandy W, Hull L, Cage E.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Understanding and rethinking identity through Luhmann’s system theory

Humanities & Social Sciences Communications
This paper develops a systems-theoretical approach to identity by integrating Luhmann’s theory of autopoietic systems with philosophical insights from Hegel, Frege, Kripke, and Lowe.
Murat Sariyar
doaj   +1 more source

Between heritage and belonging: Cultural identity reconstruction among Malaysian Chinese across generations

Acta Psychologica
Understanding how minority communities sustain cultural identity across generations remains a central concern in social psychology and cultural studies.
Jiaqi Zheng, Song Wang, Zhaoqiang Wang
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source