A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Social inclusion policy effects on democratic satisfaction in Europe: a catalyst of polarization threating the identities of privileged social groups. [PDF]
Front SociolAkinyemi IO, Groß M, Lang V.
europepmc +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Social inclusion programming for older adults living in age-friendly cities: a scoping review. [PDF]
BMJ OpenLiougas MP +3 more
europepmc +1 more source
Neuroticism predicts reactions to cues of social inclusion [PDF]
, 2008 Jaap J. A. Denissen, Lars Penke
openalex +1 more source
Social Deprivation and Exclusion of Immigrants in Germany [PDF]
This paper aims at providing empirical evidence on social exclusion of immigrants in Germany. We demonstrate that when using a conventional definition of the social inclusion index typically applied in the literature, immigrants appear to experience a ...
John P. Haisken-DeNew, Mathias Sinning
core
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
The mattering citizen: young adults with mental illness and complex needs' experiences and perceived opportunities of social inclusion. [PDF]
Front PsycholNord-Baade S +4 more
europepmc +1 more source
Hungry for reading: reading as a process of social inclusion [PDF]
, 2003 Else Benetti Marques Válio
openalex
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source