Results 71 to 80 of about 801,895 (298)

Barriers to progressing through a methadone maintenance treatment programme: perspectives of the clients in the Mid-West of Ireland’s drug and alcohol services

open access: yesBMC Health Services Research, 2018
Background The ‘perfect’ journey through an Irish Methadone Maintenance Treatment Programme (MMTP) would have a client engage appropriately with all relevant services available to them, inclusive of psychiatry, counselling, out-reach support, nursing and
Lisa Moran   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The complex and contradictory nature of alternative education provision

open access: yesCogent Education
Although most students experience relative success at school, there remains a population of educationally marginalised learners within educational settings, indicating that mainstream schools are challenged to appropriately meet the diverse needs of ...
Marnie Best
doaj   +1 more source

Reducing health inequalities in Finland: progressing or regressing?

open access: yesNordisk Välfärdsforskning, 2016
The health of the population in Finland improved dramatically during the 20th century, but differences between socioeconomic groups prevail and have even widened during the past decades.
Hannele Palosuo, Marita Sihto
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Impact of COVID-19 and the Ukrainian War on FDI in a Panel of Eastern European Economies [PDF]

open access: yesMeđunarodna politika
The COVID-19 pandemic, coupled with the Russia-Ukraine war, has had disastrous consequences for the global economy. As a result of the crisis, the normal way of conducting business has changed drastically, and, with the ongoing Russian invasion in ...
Sheereen Fauzel   +2 more
doaj   +1 more source

Social inclusion and inclusive education [PDF]

open access: yesAcademicus International Scientific Journal, 2014
The key question addressed in this article is social inclusion, as an opposite concept of social exclusion. The author provides a historical of social inclusion/exclusion terminology. Further, some of the principles of social inclusion are presented. A brief review of the literature provides key views and theories of social inclusion.
openaire   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

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